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COMPUTATIONAL ALGORITHM TO PREDICT PEAK PROFILES IN PREPARATIVE HIGH-PERFORMANCE CHROMATOGRAPHY
Korean Journal of Chemical Engineering, November 1995, 12(5), 512-515(4), 10.1007/BF02705852
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Abstract
The computational algorithm and the Prep-LEAR program have been performed on the basis of the LEA model of chromatography. This program intends for calculation of peak profiles in non-linear high-performance chromatography and uses unsimplified adsorption isotherm equations. The computational algorithm and program have been tested by applying these to experimental data of thymine adsorption under conditions of reversed-phase high-performance liquid chromatography. The results of numerical calculations for different sample size introduced agree satisfactorily with experimental data and show the characteristic properties of high-performance chromatography. The usefulness of the Prep-LEAR program was confirmed by predicting peak profiles in preparative adsorption chromatographic processes.
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References
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Glueckauf E, J. Chem. Soc., 1302 (1947)
Ha HY, Row KH, Lee WK, Sep. Sci. Technol., 22(1), 141 (1987)
Larin AV, Izv. Akad. Nauk SSSR. Ser. Khim., 236 (1983)
Larin AV, Izv. Akad. Nauk SSSR. Ser. Khim., 1235 (1983)
Larin AV, Langmuir, 3, 318 (1987)
Larin AV, Adsorpt. Sci. Technol., 6(4), 212 (1989)
Rouchon P, Schoenauer M, Valentin P, Vidal-Madjar C, Guiochon G, J. Phys. Chem., 89, 2076 (1985)
Row KH, Chromatographia, 25(11), 961 (1988)
Row KH, Choi DK, Lee YY, Korean J. Chem. Eng., 7(2), 151 (1990)
Row KH, Lee YY, Korean J. Chem. Eng., 9(2), 83 (1992)
Smit JC, Smit HC, deJager EM, Anal. Chim. Acta, 122, 1 (1980)
Snyder LR, Cox GB, J. Chromatogr., 537, 507 (1991)
Wilson JN, J. Am. Chem. Soc., 62, 1583 (1940)
