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MATHEMATICAL MODELING OF FED-BATCH BUTA- NOL FERMENTATION WITH SIMULTANEOUS PERVAPORATION
Korean Journal of Chemical Engineering, November 1996, 13(6), 612-619(8), 10.1007/BF02706028
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Abstract
A mathematical model was developed to describe a fed-batch acetone-butanol-ethanol (ABE) fermentation with simultaneous pervaporation. The model predicted satisfactorily batch or fed- batch fermentation with or without pervaporation by introducing a parameter reflecting cell activity loss during fed-batch fermentation with pervaporation. The model also predicted the effect of membrane area, membrane thickness, and sweep air flow rate on glucose consumption rate and residual butanol concentration in the fermentation broth. Glucose con- sumption rate increased by 30% by either doubling the membrane area or decreasing mem- brane thickness by half.
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References
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Contois DE, J. Gen. Microbiol., 21, 40 (1959)
Costa JM, Moreira AR, Am. Chem. Soc. Symp. Ser., 207, 501 (1983)
Fond O, Matta-El-Amouri G, Petitdemange H, Engasser JM, Appl. Microbiol. Biotechnol., 22, 195 (1985)
Geng C, Ph.D. Dissertation, "Acetone-Butanol-Ethanol Fermentation and Pervaporation by Clostridium Acetobutylicum B18," University of Minnesota, St. Paul, U.S.A. (1995)
Geng QH, Park CH, Biotechnol. Bioeng., 43(10), 978 (1994)
Geng Q, Park CH, Biotechnol. Lett., 15, 421 (1993)
Geng Q, Park CH, Janni K, Korean J. Chem. Eng., 12(3), 378 (1995)
Gottschalk G, "Bacterial Metabolism," Springer-Verlag, NY (1986)
Groot WJ, Den Reyer MCH, vander Lans RGJM, Luyben KAM, Chem. Eng. J., 46, B11 (1991)
Jarzebski AB, Goma G, Soucaille P, Bioprocess Eng., 7, 357 (1992)
Park CH, Geng Q, Rogers P, Appl. Microbiol. Biotechnol., 39, 148 (1993)
Park CH, Okos MR, Wankat PC, Biotechnol. Prog., 7, 185 (1991)
Roels JA, "Energetics and Kinetics in Biotechnology," Elsevier Biomedical Press, New York (1983)
Shukla R, Kang W, Sirkar KK, Biotechnol. Bioeng., 34, 1158 (1989)
Srivastava AK, Volesky B, Biotechnol. Bioeng., 12, 693 (1990)
Volesky B, Votruba J, "Modeling and Optimization of Fermentation Processes," Elsevier, New York (1992)
Votruba J, Volesky B, Yerushalmi L, Biotechnol. Bioeng., 28, 247 (1986)