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Effect of Operating Conditions on Adsorption of Cephalosporin C in a Column Adsorber
Korean Journal of Chemical Engineering, July 1997, 14(4), 277-284(8), 10.1007/BF02706824
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Abstract
Adsorption of cephalosporin C on a non-ionic polymeric sorbent, SP850, was studied in a column adsorber under various operating conditions such as temperature, pH, concentration, flow rate, and L/D ratio. An adsorption model was formulated by employing the surface diffusion inside resin particles. Single-species equilibrium data were simply represented by Freundlich equation. The model equations were solved numerically by an orthogonal collocation method. The model successfully simulates the adsorption behavior in a column under different operating conditions, but the considerable deviations are observed at low solution pHs, at which different ionic species may coexist.
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Costa C, Rodriques A, AIChE J., 31, 1645 (1985)
Dechow FJ, "Sparation and Purification Techniques in Biotechnology," Noyes, Park Ridge, NJ (1989)
Elander RP, Aoki H, "β-Lactam-Producing Microorganism: Their Biology and Fermentation Behavior, in Chemistry and Biology of β-Lactam Antibiotics," Academic Press, 3, 83 (1982)
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Moon H, Lee WK, J. Colloid Interface Sci., 961, 162 (1983)
Moon H, Tien C, Ind. Eng. Chem. Res., 26, 2042 (1987)
Myers AL, Prausnitz JM, AIChE J., 11, 121 (1965)
Nara K, Ohta K, Katamoto K, Mizokami N, Fukuda H, "Method for Separating Cephalosporin C," U.S. Patent, 3,926,973 (1975)
Raghavan NS, Rutheven DM, AIChE J., 29, 922 (1983)
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Ruthven DM, "Principles of Adsorption and Adsorption Processes," John Wiley & Sons, New York (1984)
Smith A, "Cephalosporins, in Comprehensive Biotechnology," Pergamon Press, 3, 163 (1985)
Villadsen J, Michelsen ML, "Solution of Differential Equation Models by Polynomial Approximation," Prentice-Hall, Englewood Cliffs (1978)
Wakao N, Funazkri, Chem. Eng. Sci., 33, 1375 (1978)
Wankat PC, "Large-Scale Adsorption Chromatography," CRC Press, Boca Raton, FL (1980)
