Articles & Issues

Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received January 9, 2000
Accepted May 9, 2001

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

All issues

Evaluation of Shear-Induced Particle Diffusivity in Red Cell Ghosts Suspensions

Woonou Cha^{1 2†} Richard L. Beissinger¹

¹Department of Chemical and Environmental Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA ²Chemicals R&D Center, SK Chemicals, Suwon, Kyungki-Do 440-748, USA

wocha@skchemicals.com

Korean Journal of Chemical Engineering, July 2001, 18(4), 479-485(7), 10.1007/BF02698294

Download PDF

Abstract

The shear-induced particle diffusivity in the red blood cell suspensions was evaluated based on the flow model and experimental results in a rectangular flow chamber. The effective diffusivity (D(e)) of solute in the particle suspensions is equal to the stationary diffusivity (D(s)) of the solute plus the shear-induced particle diffusivity (D(p)). The effective diffusivity (D(e)) of bovine serum albumin (BSA) in the red blood cell (RBC) ghost suspensions was determined under diffusion-limited conditions using a total internal reflection fluorescence (TIRF) method as a function of suspended RBC ghost volume fractions (0.05-0.7) and shear rates (200-1,000 s(-1)). The stationary diffusivity (D(s)) of BSA in RBC ghost suspensions was calculated by Meredith and Tobias model. Therefore the shear-induced particle diffusivity undergoing laminar shear flow can be evaluated. The shear-induced RBC ghost diffusivity was ranged from 0.35×10(-7) to 21.2×10(-7) cm(2)/s and it increased with increasing shear rate. Also the shear-induced RBC ghost diffusivity increased as a particle volume fraction increased as well, up to a particle volume fraction of 0.45. However, for RBC ghost volume fractions above 0.45, the shear-induced particle diffusivity decreased with increasing particle volume fraction. The shear-induced particle diffusivity in RBC ghost suspensions is a function of a particle Peclet number (or shear rate) and particle volume fractions. The dimensionless particle diffusivity (D(p)/a(2)g) was investigated as a function of particle volume fraction and these results are in good agreement with the literature values.

Keywords

Shear-Induced Particle Diffusivity Effective Diffusivity Suspension Red Blood Cell Ghost Particle Motion

References

Bird RB, Stewart WE, Lightfoot EN, "Transport Phenomena," John Wiley & Sons Inc (1960)
Cha W, Ph.D. Dissertation, "Red Blood Cell-Augmented Mass Transport of Albumin in Sheared Suspensions to Surfaces," Illinois Institute of Technology (1993)
Cha W, Beissinger RL, J. Colloid Interface Sci., 177(2), 666 (1996)
Cha W, Beissinger RL, J. Colloid Interface Sci., 178(1), 1 (1996)
Chin BD, Park OO, Korean J. Chem. Eng., 18(1), 54 (2001)
Eckstein EC, Bailey DG, Shapiro AH, J. Fluid Mech., 79, 191 (1977)
Gauthier FJ, Goldsmith HL, Mason SG, Biorheology, 9, 205 (1972)
Goldsmith HL, Fed. Proc., 30, 1578 (1971)
Goldsmith HL, Marlow JC, J. Colloid Interface Sci., 71, 383 (1979)
Jefferey GB, Proc. Roy. Soc., a102, 161 (1922)
Kim D, Ph.D. Dissertation, "Augmentation of Macromolecular Mass Transport in Sheared Suspensions: The Effective Diffusivity of Gamma Golbulin in Red Blood Cell Ghosts Suspensions," Illinois Institute of Technology (1990)
Kim D, Beissinger RL, J. Colloid Interface Sci., 159, 9 (1993)
Leal LG, J. Colloid Interface Sci., 58, 296 (1977)
Leighton D, Acrivos A, J. Fluid Mech., 181, 415 (1987)
Meredith RE, Tobias CW, J. Electrochem. Soc., 108, 286 (1968)
Yim SS, Korean J. Chem. Eng., 16(3), 308 (1999)
Zydney AL, Colton CK, Physicochemical Hydrodynamics, 10, 77 (1988)