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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received April 12, 2002
Accepted July 26, 2002

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prediction of the Solubility of 6APA in Aqueous Phase and Optimum Control Scheme for Batch Crystallization Process through pH Variation

Bahman ZareNezhad^†

Chemical Engineering Department, IUST, P.O. Box 15875-4786, Tehran, Iran

Korean Journal of Chemical Engineering, November 2002, 19(6), 992-995(4), 10.1007/BF02707222

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Abstract

Solubilities of 6APA in water at different pH and temperatures are measured. A three parameter model is proposed for predicting the aqueous solubility of this amino acid. Predicted values are in good agreement with the experimental data. The model may be used for quick and accurate evaluation of the aqueous solubility of other simple ampholytes. The proposed correlation is combined with the population balance and kinetic equations for predicting the optimum pH profiles required to maintain a constant supersaturation in a batch crystallizer. The suggested policy leads to a more uniform crystal size distribution for 6APA with C.V of 23%.

Keywords

6APA Solubility Optimum pH Profile Batch Crystallization Crystal Size Distribution

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