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Received August 13, 2003
Accepted October 15, 2003
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Application of Mesoporous MCM-48 and SBA-15 Materials for the Separation of Biochemicals Dissolved in Aqueous Solution
Department of Environmental and Chemical Engineering, Seonam University, Namwon 590-170, Korea 1Faculty of Applied Chemistry, Chonnam National University, Gwangju 500-757, Korea
hmoon@chonnam.ac.kr
Korean Journal of Chemical Engineering, January 2004, 21(1), 246-251(6), 10.1007/BF02705405
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Abstract
The application of molecular sieves for the separation and purification of biological molecules has been limited because of their available pore size (<1.3 nm). With the development of synthetic mesoporous materials, the available pore size range (1.5-10 nm) has been extended. They have pores large enough to allow access for a number of biological molecules. This work investigated the use of two mesoporous materials (MCM-48 and SBA-15) with different pore sizes and structures for adsorption of cephalosporin C as a model compound of biological molecules in terms of ethanol concentration, solution pH, and temperature. It was found that these materials have the potential for the separation and purification processes of biochemicals including antibiotics, amino acids, and proteins.
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References
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Oh JS, Shim WG, Lee JW, Kim JH, Moon H, Seo G, Chem. Eng. Data, 48, 1458 (2003)
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Smith A, "Cephalosporics, in Comprehensive Biotechnology," Pergamon Press, 3, 163 (1985)
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Zhao D, Huo Q, Feng J, Chmelka BF, Stucky GD, J. Am. Chem. Soc., 120(24), 6024 (1998)
Asenjo JA, "Separation Processes in Biotechnology," Marcel Dekker Inc., New York (1983)
Beck JS, Vartuli JC, Roth WJ, Leonowicz ME, Kresge CT, Schmitt Kd, Chu CTW, Olson DH, Sheppard EW, McCullen SB, Higgins JB, Schlenker JL, J. Am. Chem. Soc., 114, 10834 (1992)
Deere J, Magner E, Wall JG, Hodnett BK, J. Phys. Chem. B, 106(29), 7340 (2002)
Kisler JM, Dahler A, Stevens GW, O'Connor AJ, Microporous Mesoporous Mater., 44-45, 769 (2001)
Lee JW, Jung HJ, Moon H, Korean J. Chem. Eng., 14(4), 277 (1997)
Lee JW, Park HC, Moon H, Sep. Purif. Technol., 12, 1 (1997)
Lee JW, Moon H, Adsorption, 5, 381 (1999)
Lee JW, Lee JW, Shim WG, Suh SH, Moon H, J. Chem. Eng. Data, 48, 381 (2003)
Oh JS, Shim WG, Lee JW, Kim JH, Moon H, Seo G, Chem. Eng. Data, 48, 1458 (2003)
Ryoo R, Joo SH, Kim JM, J. Phys. Chem. B, 103(35), 7435 (1999)
Seo G, Kim TJ, Lim S, Ko CH, Ryoo R, Korean J. Chem. Eng., 15(6), 611 (1998)
Smith A, "Cephalosporics, in Comprehensive Biotechnology," Pergamon Press, 3, 163 (1985)
Yang WC, Shim WG, Lee JW, Moon H, Korean J. Chem. Eng., 20(5), 922 (2003)
Zhao D, Huo Q, Feng J, Chmelka BF, Stucky GD, J. Am. Chem. Soc., 120(24), 6024 (1998)
