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Received July 21, 2003
Accepted September 8, 2003
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A Novel Non-phosgene Approach to the Synthesis of Methyl N-phenyl Carbamate by a Reaction of Methanol with Phenylurea
Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan Shanxi 030001, China 1Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China
Korean Journal of Chemical Engineering, March 2004, 21(2), 378-380(3), 10.1007/BF02705423
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Abstract
A novel non-phosgene process for the synthesis of methyl N-phenyl carbamate (MPC) by a reaction of phenylurea with methanol was studied. The reaction between phenylurea and methanol was found to be a spontaneous reaction that took place in the absence of catalyst and gave MPC as the main product. Addition of a catalyst markedly influenced the reaction behavior. A basic catalyst greatly enhanced the yield of MPC, whereas an acidic catalyst promoted the formation of aniline and methyl carbamate. Moderate strength of basicity showed the best catalytic performance in the cases studied. The mechanism of reaction and catalyst functioning was discussed.
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Wan BS, Liao SJ, Yu DR, Appl. Catal. A: Gen., 183(1), 81 (1999)
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