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Received May 9, 2003
Accepted October 6, 2003
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Continuous Chromatographic Processes with a Small Number of Columns: Comparison of Simulated Moving Bed with Varicol, PowerFeed, and ModiCon
Korean Journal of Chemical Engineering, March 2004, 21(2), 454-464(11), 10.1007/BF02705435
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Abstract
The Simulated Moving Bed process and its recent extensions called Varicol, PowerFeed and ModiCon are studied, in the case where a small number of columns are used, i.e. from three to five. A multiobjective optimization approach, using genetic algorithms and a detailed model of the multicolumn chromatographic process, is applied to optimize each process separately, and allow for comparison of the different operating modes. The non-standard SMB processes achieve better performance than SMB, due to the availability of more degrees of freedom in the operating conditions of the process, namely the way to carry out asynchronous switches for Varicol, and the different flow rates and feed concentration during the switching interval for PowerFeed and for ModiCon, respectively. We also consider the possibility of combining two non-standard operating modes in a new hybrid process, and evaluate also in this case the possible performance. Finally, a critical assessment of the results obtained and of the potential for practical implementation of the different techniques is reported.
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Antos D, Seidel-Morgenstern A, Chem. Eng. Sci., 56(23), 6667 (2001)
Bhaskar V, Gupta SK, Ray AK, Rev. Chem. Eng., 16, 1 (2000)
Biressi G, Ludemann-Hombourger O, Mazzotti M, Nicoud RM, Morbidelli M, J. Chromatogr. A, 876, 3 (2000)
Denet F, Hauck W, Nicoud RM, Di Giovanni O, Mazzotti M, Jaubert JN, Morbidelli M, Ind. Eng. Chem. Res., 40(21), 4603 (2001)
DiGiovanni O, Mazzotti M, Morbidelli M, Denet F, Hauck W, Nicoud RM, J. Chromatogr. A, 919, 1 (2001)
Houwing J, Jensen TB, van Hateren SH, Billiet HAH, van der Wielen LAM, AIChE J., 49(3), 665 (2003)
Jensen TB, Reijns TGP, Billiet HAH, vanderWielen LAM, J. Chromatogr. A, 873, 149 (2000)
Kearney MM, Hieb KL, U.S. Patent, 5,102 (1992)
Kloppenburg E, Gilles ED, Chem. Eng. Technol., 22(10), 813 (1999)
Ludemann-Hombourger O, Nicoud RM, Bailly M, Sep. Sci. Technol., 35(12), 1829 (2000)
Ludemann-Hombourger O, Pigorini G, Nicoud RM, Ross DS, Terfloth G, J. Chromatogr. A, 947, 59 (2002)
Mazzotti M, Storti G, Morbidelli M, J. Chromatogr. A, 769, 3 (1997)
Mazzotti M, Storti G, Morbidelli M, J. Chromatogr. A, 786, 309 (1997)
Migliorini C, Wendlinger M, Mazzotti M, Morbidelli M, Ind. Eng. Chem. Res., 40(12), 2606 (2001)
Nicoud RM, Perrut M, French Patent, 9,205 (1992)
Pais LS, Rodrigues AE, J. Chromatogr. A, 1006, 33 (2003)
Schramm H, Kaspereit M, Kienle A, Seidel-Morgenstern A, Chem. Eng. Technol., 25(12), 1151 (2002)
Schramn H, Kaspereit M, Kienle A, Seidel-Morgenstern A, J. Chromatogr. A, 1006, 77 (2003)
Storti G, Masi M, Paludetto R, Morbidelli M, Carra S, Comput. Chem. Eng., 12, 475 (1988)
Toumi A, Engell S, Ludemann-Hombourger O, Nicoud RM, Bailly M, J. Chromatogr. A, 1006, 15 (2003)
Zang YF, Wankat PC, Ind. Eng. Chem. Res., 41(10), 2504 (2002)
Zang YF, Wankat PC, Ind. Eng. Chem. Res., 41(21), 5283 (2002)
Zhang ZY, Hidajat K, Ray AK, Morbidelli M, AIChE J., 48(12), 2800 (2002)
Zhang Z, Mazzotti M, Morbidelli M, AIChE J., 50, 625 (2004)
Zhang Z, Mazzotti M, Morbidelli M, J. Chromatogr. A, 989, 95 (2003)
Zhang Z, Mazzotti M, Morbidelli M, J. Chromatogr. A, 1006, 87 (2003)
