Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received October 14, 2003
Accepted December 28, 2003
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
Effects of Cross-Linking and Spacer Groups on beta-Cyclodextrin Bonded Liquid Chromatographic Separation
Department of Chemistry, Air Force Academy (R.O.K.), Cheong-ju, Chungbuk 363-849, Korea 1Chemical Engineering Department, Colorado School of Mines, Golden, CO 80401, USA
manhoe@hanmail.net
Korean Journal of Chemical Engineering, March 2004, 21(2), 465-468(4), 10.1007/BF02705436
Download PDF
Abstract
Mesoporous glass beads and 5 μm silica particles were modified with beta-cyclodextrin (β-CD) by means of directly bonding, linking spacer group, and cross-linking agent. The selectivities of the β-CD modified silica particles were measured by simple column chromatography to separate a model mixture of 1- and 2-hydroxy-naphthalene (naphthols) and ortho, meta, and para-xylene. In the packed column chromatography experiments, two major controlling factors (inclusion complex formation effect and steric hindrance effect of the analytes) on the separations were observed. The elusion orders of the β-CD directly bonded glass beads were meta-, para-, ortho-xylene and 1-naphthol, 2-naphthol. The phenomena of β-CD pore blocking and narrowing by spacer groups and cross-linking agent were observed. The spacer group and cross-linking agent decreased inclusion complex formation of 2-naphthol.
Keywords
References
Armstrong DW, DeMond WJ, Chromatogr. Sci., 22, 411 (1984)
Armstrong DW, "Bonded Phase Material for Chromatographic Separation," U.S. Patent, 4,539,399 (1985)
Armstrong DW, DeMond W, Alak A, Anal. Chem., 57, 234 (1985)
Kim M, Way JD, Baldwin RM, Korean J. Chem. Eng., 19(5), 876 (2002)
Kim M, Way JD, Baldwin RM, Korean J. Chem. Eng., 20(3), 528 (2003)
Kim YD, Lee JK, Cho YS, Korean J. Chem. Eng., 18(6), 971 (2001)
Krieg HM, Breytenbach JC, Keizer K, J. Membr. Sci., 164(1-2), 177 (2000)
Szejtli J, Chem. Rev., 98(5), 1743 (1998)
Armstrong DW, "Bonded Phase Material for Chromatographic Separation," U.S. Patent, 4,539,399 (1985)
Armstrong DW, DeMond W, Alak A, Anal. Chem., 57, 234 (1985)
Kim M, Way JD, Baldwin RM, Korean J. Chem. Eng., 19(5), 876 (2002)
Kim M, Way JD, Baldwin RM, Korean J. Chem. Eng., 20(3), 528 (2003)
Kim YD, Lee JK, Cho YS, Korean J. Chem. Eng., 18(6), 971 (2001)
Krieg HM, Breytenbach JC, Keizer K, J. Membr. Sci., 164(1-2), 177 (2000)
Szejtli J, Chem. Rev., 98(5), 1743 (1998)
