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Received September 1, 2004
Accepted November 15, 2004
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The Ion-exchange Kinetics of SAM+/H+ System with JK110 Resin
Pharmaceutical Informatics Institute, Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310027, China 1Institute of Bioengineering, Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou 310027, China
cenpl@zju.edu.cn
Korean Journal of Chemical Engineering, January 2005, 22(1), 121-126(6), 10.1007/BF02701473
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Abstract
S-adenosyl-L-methionine (SAM) is an important small molecule with many medical interests. The ionexchange kinetics of SAM+/H+ system with JK110 resin has been studied in this work. The results showed that intraparticle diffusion was the rate limiting step in the ion-exchange process. A suitable model of particle diffusion has been proposed to describe the effects of pH, temperature and SAM concentration in the solution on the ion-exchange rate. By simulating experimental data with model equation, some parameters such as diffusion constant B, internal diffusion coefficient Di and activation energy Ea are obtained.
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