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Received June 7, 2006
Accepted August 28, 2006
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Pore diffusion and solid diffusion models: Application in countercurrent chromatographic separation process
Division of Chemical and Biomolecular Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637722
xwang@ntu.edu.sg
Korean Journal of Chemical Engineering, January 2007, 24(1), 121-126(6), 10.1007/s11814-007-5021-4
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Abstract
Difference and equivalence of two approaches for countercurrent chromatographic separation process were discussed. Although the two approaches are different in the TCC process in terms of model equations and definition of phase concentrations and flow rate ratios as well as complete separation regions expressed by flow rate ratios etc., they are equivalent in the SMB process. Experimental and simulation results are consistent with theoretical analysis. In application of the SMB process, it is of crucial importance to use these two approaches consistently.
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References
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Storti G, Mazzotti M, Morbidelli M, Carra S, AIChE J., 39, 471 (1993)
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Zhong GM, Guiochon G, Chem. Eng. Sci., 52(23), 4403 (1997)
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Zhang Z, Mazzotti M, Morbidelli M, Korean J. Chem. Eng., 21(2), 454 (2004)
Azevedo DCS, Rodrigues AE, AIChE J., 45(5), 956 (1999)
Erdem G, Morari M, Amanullah M, Mazzotti M, Morbidelli M, AIChE J., 52(4), 1481 (2006)
Houwing J, van Hateren SH, Billiet HAH, van der Wielen LAM, J. Chromatogr. A, 952, 85 (2002)
Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC, Beck JS, Nature, 359, 710 (1992)
Lee KB, Mun S, Cauley F, Cox GB, Wang NHL, Ind. Eng. Chem. Res., 45(2), 739 (2006)
Mallmann T, Burris BD, Ma Z, Wang NHL, AIChE J., 44(12), 2628 (1998)
Mazzotti M, Storti G, Morbidelli M, J. Chromatogr. A, 769, 3 (1997)
Mihlbachler K, Seidel-Morgenstern A, Guiochon G, AIChE J., 50(3), 611 (2004)
Nicolaos A, Muhr L, Gotteland P, Nicoud RM, Bailly M, J. Chromatogr. A, 908, 71 (2001)
Park BJ, Lee CH, Koo YM, Korean J. Chem. Eng., 22(3), 425 (2005)
Pedeferri M, Zenoni G, Mazzotti M, Morbidelli M, Chem. Eng. Sci., 54(17), 3735 (1999)
Ruthven DM, Ching CB, Chem. Eng. Sci., 44, 1011 (1989)
Schulte M, Strube J, J. Chromatogr. A, 906, 399 (2001)
Storti G, Mazzotti M, Morbidelli M, Carra S, AIChE J., 39, 471 (1993)
Wang X, Liu Y, Ching CB, Sep. Purif. Technol., 50, 204 (2006)
Zhong GM, Guiochon G, Chem. Eng. Sci., 52(23), 4403 (1997)
Zhang Y, Hidajat K, Ray AK, Biochem. Eng. J., 21, 111 (2004)
Zhang Z, Mazzotti M, Morbidelli M, Korean J. Chem. Eng., 21(2), 454 (2004)
