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Received June 2, 2006
Accepted February 12, 2007
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Preparation of poly(L-lactic acid) submicron particles in aerosol solvent extraction system using supercritical carbon dioxide
Clean Technology Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Sungbuk-gu, Seoul 136-791, Korea 1Department of Chemical and Biomolecular Engineering, Sogang University, 1 Sinsu-dong, Mapo-gu, Seoul 121-742, Korea
limjs@sogang.ac.kr
Korean Journal of Chemical Engineering, September 2007, 24(5), 860-865(6), 10.1007/s11814-007-0055-1
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Abstract
The aerosol solvent extraction system process (ASES), which is one of the supercritical anti solvent processes (SAS), was used to produce poly(L-lactic acid) (PLLA) into the submicron particles. Dichloromethane (DCM, CH2Cl2) and carbon dioxide were selected as a solvent and as an antisolvent for PLLA, respectively. The objective of this study was to investigate the effect of the various process parameters such as temperature, pressure, and solution concentration on PLLA particles. With increasing temperature and pressure, particle size was increased. Also, higher PLLA concentration led to larger particle size and broader particle size distribution. A scanning electron microscope (SEM) was used to observe the morphology and size of PLLA particles recrystallized by ASES process. The mean particle size and its distribution of processed particles were measured by using a laser diffraction particle size analyzer (PSA).
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References
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Lefebvre AH, Atomization and sprays, Taylor & Francis, 309 (1989)
Lee YW, HWAHAK KONGHAK, 41(6), 679 (2003)
Andrew JY, John JD, Atomization of melts, Clarendon press, Oxford, 25 (1994)
Mukhopadhyay M, Dalvi SV, J. Supercrit. Fluids, 30, 333 (2004)
Paulaitis ME, Penninger JML, Gray RD, Davidson, Chemical engineering at supercritical fluid conditions, Ann Arbor, MI, Ann Arbor Science (1983)
de Filippi RP, Chung ME, Laboratory evaluation of critical fluid extraction for environmental applications, Report EPA-600/2-85-045. April (1980)
Jarmer DJ, Lengsfeld CS, Randolph TW, J. Supercrit. Fluids, 27, 317 (2003)
Song KH, Lee CH, Lim JS, Lee YW, Korean J. Chem. Eng., 19(1), 139 (2002)
Reverchon E, Porta GD, de Rosa I, Subra P, Letourneur D, J. Supercrit. Fluids, 18, 239 (2002)
Reverchon E, de Marcon I, Caputo G, Porta GD, J. Supercrit. Fluids, 20, 293 (2003)
