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Received August 21, 2006
Accepted May 7, 2007
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Improvement of bioavailability of water insoluble drugs: Estimation of intrinsic bioavailability
1Research Division, Insilicotech Co., Ltd., Seongnam 463-943, Korea 2Interdisciplinary Program in Powder Technology, Graduate School, Pusan National University, Busan 609-735, Korea 3Department of Pharmaceutical Manufacturing, Pusan National University, Busan 609-735, Korea
wschoi@pusan.ac.kr
Korean Journal of Chemical Engineering, January 2008, 25(1), 171-175(5), 10.1007/s11814-008-0031-4
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Abstract
A series of attempts to enhance the bioavailability of water insoluble drugs have been made by the fine grinding technique using a planetary ball mill in wet milling process. Here, the possibility of improving the dissolution properties of water insoluble drugs such as ursodeoxycholic acid (UDCA), diphenyl hydrantoin (phenytoin) and biphenyl dimethyl dicarboxylate (DDB) based on ultra-fine grinding process has been discussed with comparison to experimental data. Also examined was the intrinsic bioavailability estimated based on a molecular modeling approach and thermophysical data.
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Cheng A, Merz KM, J. Med. Chem., 46, 3572 (2003)
Arlt W, in Private communication on the prediction of thermophysical data, University of Erlangen, Germany (2005)
