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Received March 21, 2007
Accepted August 5, 2007
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Recrystallization of phenylbutazone using supercritical fluid antisolvent process
Department of Chemical Engineering, Kyungpook National University, Daegu, 702-701, Korea
Korean Journal of Chemical Engineering, May 2008, 25(3), 575-580(6), 10.1007/s11814-008-0097-z
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Abstract
Phenylbutazone was recrystallized from its solutions by using a supercritical fluid antisolvent process. It was dissolved in acetone and supercritical carbon dioxide was injected into the solution, thereby inducing supersaturation and particle formation. Variation in the physical properties of the recrystallized phenylbutazone was investigated as a function of the crystallizing temperature and the carbon dioxide injection rate. The recrystallized particles showed cleaner surfaces and more ordered morphology compared to the particles obtained by other methods such as solvent evaporation. X-ray diffraction patterns indicated that the crystallinity of the particles had been modified upon the recrystallization. Differential scanning calorimetry measurement revealed that the crystallizing temperature influenced the thermal stability of the resulting crystals. Larger crystals were produced when the carbon dioxide injection rate was reduced.
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Li G, Chu J, Song ES, Row KH, Lee KH, Lee YW, Korean J. Chem. Eng., 23(3), 482 (2006)
Sacha GA, Schmitt WJ, Nail SL, Pharm. Dev. Technol., 11, 187 (2006)
Miguel F, Martin A, Gamse T, Cocero MJ, J. Supercrit. Fluids, 36(3), 225 (2006)
Reverchon E, De Marco I, Powder Technol., 164(3), 139 (2006)
Gimeno M, Ventosa N, Boumghar Y, Fournier J, Boucher I, Veciana J, J. Supercrit. Fluids, 38(1), 94 (2006)
Park SJ, Jeon SY, Yeo SD, Ind. Eng. Chem. Res., 45(7), 2287 (2006)
Jarmer DJ, Lengsfeld CS, Anseth KS, Randolph TW, J. Pharm. Sci., 94, 2688 (2005)
Matsuda Y, Tatsumi E, Chiba E, Miwa Y, J. Pharm. Sci., 73, 1453 (1984)
Yeo SD, Kim MS, Lee JC, J. Supercrit. Fluids, 25(2), 143 (2003)
Cullity BD, Elements of X-ray diffraction, 2nd, Ed., Addison-Wesley Publishing Co., Massachusetts (1978)
Ford JL, Timmins P, Pharmaceutical thermal analysis, Ellis-Horwood Ltd., Chichester, England (1989)
