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Received October 16, 2007
Accepted January 27, 2008
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Micronization of arbutine using supercritical anti-solvent
School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-744, Korea
Korean Journal of Chemical Engineering, May 2008, 25(3), 581-584(4), 10.1007/s11814-008-0098-y
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Abstract
Arbutine has been used as skin whitening agent in cosmetics and pharmaceuticals. The objective of this study was to precipitate arbutine micro-particles using a supercritical anti-solvent. Ethanol and supercritical CO2 were used as solvent and anti-solvent, respectively, under various conditions. The effects of pressure, temperature and solution flow rate on the particles were studied. The particle size and morphology were analyzed by field emission scanning electron microscopy.
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References
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Perrut M, Jung J, Leboeuf F, Int. J. Pharm., 288, 3 (2005)
Hastings DR, Hendricks JA, US Patent 89/416855 (1989)
Debenedetti PG, Lim GB, Prud’Homme RK, European Patent, 0542314 (1992)
Yeo SD, Lim GB, Debenedetti PG, Bernstein H, Biotechnol. Bioeng., 41, 341 (1993)
Schmitt WJ, Salada MC, Shook GG, Speaker SM, AIChE J., 41(11), 2476 (1995)
Thiering R, Dehghani F, Dillow A, Foster NR, J. Chem. Technol. Biotechnol., 75(1), 29 (2000)
Reverchon E, Della Porta G, Falivene MG, J. Supercrit. Fluids, 17(3), 239 (2000)
Amaro-Gonzalez D, Mabe G, Zabaloy M, Brignole EA, J. Supercrit. Fluids, 17(3), 249 (2000)
Choi S, Oh K, Kim H, Clean Technol., 10(4), 215 (2004)
Li G, Chu J, Song ES, Row KH, Lee KH, Lee YW, Korean J. Chem. Eng., 23(3), 482 (2006)
Kim MY, Yoo KP, Lim JS, Korean J. Chem. Eng., 24(5), 860 (2007)
