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Received January 20, 2008
Accepted March 6, 2008
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Effects of di-(2-ethylhexyl) phthalate (DEHP) released from laboratory equipments
Department of Biological Engineering, Inha University, Incheon 402-751, Korea
ekkim@inha.ac.kr
Korean Journal of Chemical Engineering, September 2008, 25(5), 1136-1139(4), 10.1007/s11814-008-0186-z
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Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in polyvinyl chloride (PVC) manufacturing and is an endocrine disrupter. DEHP was released from laboratory tubing and resins during solvent extraction of natural plants to isolate skin depigmenting compounds. Contamination of DEHP significantly interfered with the purification of depigmenting compounds, since DEHP showed high depigmenting activity (IC50=24 μM) and did not show cell toxicity up to 20 μM. Release of DEHP depended on the composition of tubing materials and solvents used in the extraction process. This result provides practical information for the proper selection of laboratory materials and solvents especially in the extraction and isolation of skin depigmenting compounds for cosmetic ingredients.
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Williams DT, J. Agric. Food Chem., 21, 1128 (1973)
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Riley PA, Pigment Cell Res., 16, 548 (2003)
Petit L, Pierard GE, Int. J. Cosmet. Sci., 25, 169 (2003)
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Du Q, Shen L, Xiu L, Jerz G, Winterhalter P, Food Addit. Contam., 23, 552 (2006)
