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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received October 4, 2007
Accepted January 21, 2008

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Thermal decomposition kinetics of 5-fluorouracil from thermogravimetric analysis

Qing-yang Liu Yi-ling Bei^† Gui-bin Qi Yuan-jun Ding

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R., China

Korean Journal of Chemical Engineering, September 2008, 25(5), 980-981(2), 10.1007/s11814-008-0158-3

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Abstract

The thermal decomposition kinetics of 5-fluorouracil was studied by thermogravimetric analysis methodology. The decomposition activation energy was calculated by using Ozawa method by means of TGA in nitrogen atmosphere. Moreover, the decomposition mechanism and pre-factor were obtained by Coats-Redfern and Achar methods, respectively. It is found that the decomposition activation energy of fluorouracil is 105 kJ·mol.1. The decomposition mechanisms obtained by Coats-Redfern and Achar methods are G(α)=[-ln(1-α)]2/3 and f(α)=1.5(1-α)[-ln(1-α)1/3 respectively, lnA is 21.40 min-1.

Keywords

5-Fluorouracil Thermal Degradation Kinetics Decomposition Activation Energy Solid-state Function

References

Mori N, Glunde K, Takagi T, Cancer Res., 67, 11284 (2007)
Gao H, Wang YN, J. Control. Release, 107, 158 (2005)
Yoon SJ, Choi YC, Lee SH, Lee JG, Korean J. Chem. Eng., 24(3), 512 (2007)
Sevim F, Demir F, Bilen M, Okur H, Korean J. Chem. Eng., 23(5), 736 (2006)
Kim SH, Kim SS, Chun BH, Jeon JK, Korean J. Chem. Eng., 22(4), 573 (2005)
Li R, Bu J, Korean J. Chem. Eng., 21(1), 98 (2004)
Krongauz VV, Ling MTK, Woo L, Purohit U, Thermochim. Acta, 457(1-2), 35 (2007)
Ozawa T, Bull. Chem. Soc. Jpn., 38, 1881 (1965)
Coats AW, Redfern JP, Nature, 4914, 68 (1964)
Satava VJ, Therm Anal., 2, 423 (1971)
Li CR, Tang TB, Thermochim. Acta, 325(1), 43 (1999)