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Received December 29, 2007
Accepted April 13, 2008
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CMC and dynamic properties of poly(VA-b-St) copolymer micelles for drug delivery
School of Chemistry & Chemical Engineering, Guangxi University, No. 100 Daxue Road, Nanning, Guangxi 530004, P.R. China 1Department of Fiber & Polymer Engineering, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Korea
lighuas@gxu.edu.cn
Korean Journal of Chemical Engineering, November 2008, 25(6), 1444-1447(4), 10.1007/s11814-008-0237-5
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Abstract
The polymeric micelles from amphiphilic block copolymer poly(vinyl alcohol-b-styrene) (poly(VA-b-St)) with different syndiotacticity of poly(vinyl alcohol) (PVA) block were prepared by dialysis against water. Critical micelle concentration (CMC) and dynamic properties of poly(VA-b-St) copolymeric micelles were investigated by fluorescence techniques. From the fluorescence emission spectrum measurements using pyrene as a fluorescence probe, the observed CMC value was in the range of 0.125-4.47 mg/L. The CMC value increased with decreasing the weight ratio of PS to PVA block and with increasing the syndiotacticity of PVA block. The rate of pyrene release was very slow for block copolymers containing PVA block with higher syndiotacticity, which indicates that their micelles have increased kinetic stability.
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Huang X, Huang J, Colloid & Polym. Sci., 277, 291 (1999)
Rosler A, Vandermeulen GWM, Klok HA, Advanced Drug Delivery Reviews, 53, 95 (2001)
Xu R, Winnik MA, Hallett FR, Riess G, Croucher MD, Macromolecules, 24, 87 (1991)
Li GH, Cho CG, Colloid & Polymer Science, 283, 946 (2005)
Li GH, Cho CG, Macromol. Res., 10(6), 339 (2002)
Kwon GS, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K, Langmuir, 9, 945 (1993)
Kabanov AV, Nazarova IR, Astafieva IV, Batrakova EV, Alakhov VY, Yaroslavov AA, Kabanov VA, Macromolecules, 28(7), 2303 (1995)
Kalyanasundaram K, Thomas JK, J. Am. Chem. Soc., 99, 2039 (1977)
Cao T, Munk P, Ramireddy C, Tuzar Z, Webber SE, Macromolecules, 24, 6300 (1991)
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Kankokai K, PVA no Sekai, Chapter 2, Kyoto (1992)
Yoshitaka N, Nakano T, Okamoto Y, Gotoh Y, Nagura M, Polymer, 42(24), 9679 (2001)
