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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received May 16, 2008
Accepted June 24, 2008

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nonlinear isotherm of benzene and its derivatives by frontal analysis

Xiaolong Wan Ju Weon Lee Kyung Ho Row^†

Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon 402-751, Korea

rowkho@inha.ac.kr

Korean Journal of Chemical Engineering, January 2009, 26(1), 182-188(7), 10.1007/s11814-009-0030-0

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Abstract

Abstract.Adsorption behavior of a solute is one of the most important factors to consider when designing a batch and a continuous liquid chromatographic separation process. In liquid chromatography, this behavior is based on the adsorption equilibrium between the liquid mobile-phase and solid stationary-phase. However, most retention models have been developed under a linear adsorption isotherm: very few researchers have investigated the relationship between_x000D_ the adsorption parameters and the mobile phase composition, and some empirical models have been introduced. In this work, adsorption isotherms were obtained by a frontal analysis for three small molecular compounds (benzene, toluene, and chlorobenzene) on a commercial C18 bonded silica column. The absorption based on the Langmuir, Freundlich, and Langmuir-Freundlich models were investigated according to changes of the composition of methanol highly_x000D_ enriched eluent. The calculations and analysis of the coefficients obtained for the three models confirm that the adsorption data for solutes are best modeled with the Langmuir-Freundlich isotherm. In spite of the acceptable accuracy, Langmuir and Freundlich isotherm models couldn’t satisfactorily describe the mechanism and provide objective information on the physical nature of the absorption.

Keywords

Adsorption Isotherm Modeling Frontal Analysis Mobile Phase Composition

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