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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received December 19, 2008
Accepted December 30, 2008

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Recrystallization of tetracycline hydrochloride using supercritical anti-solvent process

Junho Chu Hanho Lee Hwayong Kim Youn-Woo Lee^†

School of Chemical & Biological Engineering and Institute of Chemical Process, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-744, Korea

Korean Journal of Chemical Engineering, July 2009, 26(4), 1119-1124(6), 10.1007/s11814-009-0186-7

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Abstract

Tetracycline hydrochloride (TTC) was micronized by an Aerosol Solvent Extraction System (ASES) using supercritical CO2. The effects of solvent, pressure and temperature of CO2, solution concentration, and solution feed rate on particle size were investigated. Mean particle sizes of processed TTC were 0.16-0.31 μm, but the morphologies of processed particles were affected by agglomeration between the primary particles. Mean particle sizes of unprocessed_x000D_ TTC were ca. 200 μm and the shapes were irregular with rough surfaces. Especially, particle sizes increased from 0.18 to 0.31 μm as CO2 temperature increased. In addition, particle sizes increased from 0.18 to 0.23 μm as TTC concentration increased. Powder X-Ray diffractometry revealed that processed particles were amorphous whereas unprocessed particles showed strong crystallinity.

Keywords

Tetracycline Hydrochloride Supercritical Carbon Dioxide ASES Recrystallization

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