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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received February 2, 2009
Accepted March 15, 2009

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Preparation and characterization of PVA/PVP/glycerin/antibacterial agent hydrogels made by γ-irradiation followed by freeze-thawing

Young-Chang Nho^1† Youn-Mook Lim¹ Hui-Jeong Gwon^{1 2} Eun-Kyung Choi³

¹Radiation Research Center for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeonbuk 580-185, Korea ²Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science Technology, Daejeon 305-701, Korea ³Department of Industrial Chemistry, Chungnam National University, Daejeon 305-764, Korea

Korean Journal of Chemical Engineering, November 2009, 26(6), 1675-1678(4), 10.1007/s11814-009-0231-6

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Abstract

Hydrogels for wound dressings from a mixture of poly(vinyl alcohol) (PVA), poly(N-vinylpyrrolidone) (PVP), glycerin and an antibacterial agent were obtained by a γ-irradiation combined with freeze-thawing. The physical properties such as the gelation and swelling degree of the hydrogels were examined. When the PVP/PVA ratio was 6 : 4 (wt%) and prepared by combined irradiation and freeze-thawing, it showed an excellent swelling capacity (>1,200%)._x000D_ The antibacterial effect of the hydrogels containing the antibacterial agents was observed to be effective as the concentration of antibacterial agents increased. The results demonstrated that hydrogel in a proper blending ratio could be used as a wound dressing that can accelerate wound healing with an antibacterial effect.

Keywords

Hydrogels Radiation Antibacterial Freeze-thawing

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