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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received May 25, 2009
Accepted August 2, 2009

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats

Wol-Suk Cha Ji-Lu Ding Hyun-Jae Shin Jong-Soo Kim¹ Youn-Soon Kim² DuBok Choi^3† Hee-Duck Lee⁴ Hyeong-Bong Kang⁵ Chul-Won Lee⁵

Department of Biochemical Engineering, Chosun University, Gwangju 501-759, Korea ¹Division of Chemical Engineering, Chonbuk National University, Jeonju 561-756, Korea ²Department of Home Economics Education, Chosun University, Gwangju 501-759, Korea ³Department of Environmental Health, Cho-dang University, Chonnam 534-800, Korea ⁴Korea Advanced Food Research Institute, Seoul 137-850, Korea ⁵Defense Agency for Technology and Quality, Seoul 130-650, Korea

Korean Journal of Chemical Engineering, November 2009, 26(6), 1696-1699(4), 10.1007/s11814-009-0340-2

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Abstract

This study was performed to investigate the effects of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats. The blood glucose concentration was similar to that of the control at 30 min, but after 60 min of glucose administration the blood glucose concentration rapidly decreased, and after 120 min was 100.7±4.0 mg/dL, representing an approximate 50% decrease compared to the control. In the case of the diabetic rats induced_x000D_ by streptozotocin, the concentration of blood glucose was decreased from 362.0±16.7 to 204.5±11.4 mg/dL after 20 days of administration. HDL- and LDL-cholesterol concentrations were 39.0±4.3 mg/L and 13.2±3.4 mg/dL, respectively, representing an approximate increase of 73% and approximate decrease of 76%, respectively, compared to the control. The activities of aspartate aminotransferase and alanine transaminase were increased. On the other hand, activities of amylase, alkaline phosphatase, lactate dehydrogenase, glutamic oxaloacetic transaminase, and glutamic pyruvic transaminase were decreased compared to that of the control. No difference was evident between test and control rats with respect to white blood cell, red blood cell, hemocyte, hemoglobin, hematocrit, and platelet counts. These results indicate that F. pinicola extract is useful as a preventative and treatment agent for damage of liver and kidney cells.

Keywords

F. pinicola Blood Glucose Lipid Metabolism Cholesterol

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