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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received April 14, 2009
Accepted July 24, 2009

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Simulated moving-bed for separation of mandelic acid racemic mixtures

Eun Lee Moon Bae Park Jong Min Kim¹ Woo Sik Kim² In Ho Kim^†

Department of Chemical Engineering, Chungnam National University, Daejeon 305-764, Korea ¹Department of Chemical Engineering, Dong-A University, Busan 604-714, Korea ²School of Applied Chemistry, Kyung Hee University, Yongin 446-701, Korea

ihkim@cnu.ac.kr

Korean Journal of Chemical Engineering, January 2010, 27(1), 231-234(4), 10.1007/s11814-009-0339-8

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Abstract

Two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Consequently, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture. Simulated moving bed (SMB) is a chromatographic process that operates continuously without losing the enantiomeric purity of outlet streams from SMB. The present work describes the enantioseparation of mandelic acid in a labscale SMB unit. Chiral stationary phase was made by packing Kromasil TBB (O,O'-bis(4-tert-buylbenzoyl) -N,N'-diallyl-L-tartar diamid ) gel into empty columns. The outlet streams were sampled and analyzed by an analytical HPLC. Analysis indicated that purity values range from 82% to 94% according to the change of extract stream flow rate.

Keywords

Mandelic Acid SMB Kromasil TBB Column

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