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- In relation to this article, we declare that there is no conflict of interest.
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Received March 5, 2009
Accepted June 21, 2009
- This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
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A new approach for optimization of electrospun nanofiber formation process
University of Guilan, P.O. Box 3756, Rasht, Iran
Haghi@Guilan.ac.ir
Korean Journal of Chemical Engineering, January 2010, 27(1), 340-354(15), 10.1007/s11814-009-0309-1
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Abstract
Precise control of fiber diameter during electrospinning is very crucial for many applications. A systematic and quantitative study on the effects of processing variables enables us to control the properties of electrospun nanofibers. In this contribution, response surface methodology (RSM) was employed to quantitatively investigate the simultaneous effects of four of the most important parameters, namely solution concentration (C), spinning distance (d), applied voltage (V) and volume flow rate (Q), on mean fiber diameter (MFD) as well as standard deviation of fiber diameter (StdFD) in electrospinning of polyvinyl alcohol (PVA) nanofibers.
Keywords
References
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Li D, Xia YN, Adv. Mater., 16(14), 1151 (2004)
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Haghi AK, Akbari M, Phys. Stat. Sol. A, 204, 1830 (2007)
Gibson PW, Schreuder-Gibson HL, Rivin D, AIChE J., 45(1), 190 (1999)
Ziabari M, Mottaghitalab V, Haghi AK, Korean J. Chem. Eng., 25(4), 923 (2008)
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Khil MS, Cha DI, Kim HY, Kim IS, Bhattarai N, J. Biomed. Mater. Res. Part B: Appl. Biomater., 67, 675 (2003)
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Aussawasathien D, Dong JH, Dai L, Synthetic Met., 54, 37 (2005)
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Moroni L, Licht R, de Boer J, de Wijn JR, van Blitterswijk CA, Biomaterials, 27, 4911 (2006)
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Oka M, Ushio K, Kumar P, Ikeuchi K, Hyon SH, Nakamura T, Fujita H, P. I. Mech. Eng. H, 214, 59 (2000)
Burczak K, Gamian E, Kochman A, Biomaterials, 17, 2351 (1996)
Li JK, Wang N, Wu XS, J. Control. Release, 56, 117 (1998)
Hoffman AS, Adv. Drug Delivery Rev., 43, 3 (2002)
Zeng J, Aigner A, Czubayko F, Kissel T, Wendorff JH, Greiner A, Biomacromolecules, 6(3), 1484 (2005)
Hong KH, Polym. Eng. Sci., 47(1), 43 (2007)
Ziabari M, Mottaghitalab V, Haghi AK, Korean J. Chem. Eng., 25(4), 919 (2008)
Ziabari M, Mottaghitalab V, Haghi AK, Braz. J. Chem. Eng., 26, 53 (2009)
Ziabari M, Mottaghitalab V, McGovern ST, Haghi AK, Nanoscale Res. Lett., 2, 597 (2007)
Ziabari M, Mottaghitalab V, Haghi AK, Korean J. Chem. Eng., 25(4), 905 (2008)
Sperling LH, Introduction to physical polymer science, 4th ed., Wiley, New Jersey (2006)
Tacx JCJF, Schoffeleers HM, Brands AGM, Teuwen L, Polymer, 41(3), 947 (2000)
Ko FK, Nanofiber technology, in: Gogotsi Y (Ed.), Nanomaterials handbook, CRC, Boca Raton (2006)
Koski A, Yim K, Shivkumar S, Mater. Lett., 58, 493 (2004)
Montgomery DC, Design and analysis of experiments, 5th ed., Wiley, New York (1997)
Dean A, Voss D, Design and analysis of experiments, Springer, New York (1999)
Box GEP, Draper NR, Response surfaces, mixtures, and ridge analyses, Wiley, New Jersey (2007)
Carley KM, Kamneva NY, Reminga J, Response surface methodology, CASOS Technical Report, CMU-ISRI-04-136 (2004)
Weisberg S, Applied linear regression, 3rd ed., Wiley, New Jersey (2005)
Zhang C, Yuan X, Wu L, Han Y, Sheng J, Eur. Polym. J., 41, 423 (2005)
Li Q, Jia Z, Yang Y, Wang L, Guan Z, Preparation and properties of poly(vinyl alcohol) nanofibers by electrospinning, Proceedings of IEEE International Conference on Solid Dielectrics, Winchester, U.K. (2007)
Mit-uppatham C, Nithitanakul M, Supaphol P, Macromol. Chem. Phys., 205, 2327 (2004)
Ryu YJ, Kim HY, Lee KH, Park HC, Lee DR, Eur. Polym. J., 39, 1883 (2003)
Jarusuwannapoom T, Hongrojjanawiwat W, Jitjaicham S, Wannatong L, Nithitanakul M, Pattamaprom C, Koombhongse P, Rangkupan R, Supaphol P, Eur. Polym. J., 41, 409 (2005)
Baker SC, Atkin N, Gunning PA, Granville N, Wilson K, Wilson D, Southgate J, Biomaterials, 27, 3136 (2006)
Sukigara S, Gandhi M, Ayutsede J, Micklus M, Ko F, Polymer, 44(19), 5721 (2003)
Yuan X, Zhang Y, Dong C, Sheng J, Polym. Int., 53, 1704 (2004)
Ki CS, Baek DH, Gang KD, Lee KH, Um IC, Park YH, Polymer, 46(14), 5094 (2005)
Deitzel JM, Kleinmeyer J, Harris D, Tan NCB, Polymer, 42(1), 261 (2001)
Buchko CJ, Chen LC, Shen Y, Martin DC, Polymer, 40(26), 7397 (1999)
Lee JS, Choi KH, Do Ghim H, Kim SS, Chun DH, Kim HY, Lyoo WS, J. Appl. Polym. Sci., 93(4), 1638 (2004)
Fennessey SF, Farris RJ, Polymer, 45(12), 4217 (2004)
Kidoaki S, Kwon IK, Matsuda T, Biomaterials, 26, 37 (2005)
Zong XH, Kim K, Fang DF, Ran SF, Hsiao BS, Chu B, Polymer, 43(16), 4403 (2002)
Li D, Xia Y, Nano. Lett., 3, 555 (2003)
Jin WZ, Duan HW, Zhang YJ, Li FF, Nonafiber membrane of EVOH-based ionomer by electrospinning, Proceedings of the 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Zhuhai, China (2006)
Mo XM, Xu CY, Kotaki M, Ramakrishna S, Biomaterials, 25, 1883 (2004)
Zhao SL, Wu XH, Wang LG, Huang Y, J. Appl. Polym. Sci., 91(1), 242 (2004)
Doshi J, Reneker DH, J. Electrostatics, 35, 151 (1995)
Fong H, Reneker DH, Electrospinning and the formation of nanofibers, in: Salem DR (Ed.), Structure formation in polymeric fibers, Hanser, Cincinnati (2001)
Li D, Xia YN, Adv. Mater., 16(14), 1151 (2004)
Derch R, Greiner A, Wendorff JH, Polymer nanofibers prepared by electrospinning, in: Schwarz JA, Contescu CI, Putyera K (Eds.), Dekker encyclopedia of nanoscience and nanotechnology, CRC, New York (2004)
Haghi AK, Akbari M, Phys. Stat. Sol. A, 204, 1830 (2007)
Gibson PW, Schreuder-Gibson HL, Rivin D, AIChE J., 45(1), 190 (1999)
Ziabari M, Mottaghitalab V, Haghi AK, Korean J. Chem. Eng., 25(4), 923 (2008)
Huang ZM, Zhang YZ, Kotaki M, Ramakrishna S, Compos. Sci. Technol., 63, 2223 (2003)
Li M, Mondrinos MJ, Gandhi MR, Ko FK, Weiss AS, Lelkes PI, Biomaterials, 26, 5999 (2005)
Boland ED, Coleman BD, Barnes CP, Simpson DG, Wnek GE, Bowlin GL, Acta Biomater., 1, 115 (2005)
Lannutti J, Reneker D, Ma T, Tomasko D, Farson D, Mater. Sci. Eng. C, 27, 504 (2007)
Zeng J, Yang L, Liang Q, Zhang X, Guan H, Xu C, Chen X, Jing X, J. Control. Release, 105, 43 (2005)
Kenawy ER, Bowlin GL, Mansfield K, Layman J, Simpson DG, Sanders EH, Wnek GE, J. Control. Release, 81, 57 (2002)
Khil MS, Cha DI, Kim HY, Kim IS, Bhattarai N, J. Biomed. Mater. Res. Part B: Appl. Biomater., 67, 675 (2003)
Min BM, Lee G, Kim SH, Nam YS, Lee TS, Park WH, Biomaterials, 25, 1289 (2004)
Qin XH, Wang SY, J. Appl. Polym. Sci., 102(2), 1285 (2006)
Park HS, Park YO, Korean J. Chem. Eng., 22(1), 165 (2005)
Kim JS, Reneker DH, Polym. Eng. Sci., 39(5), 849 (1999)
Lee SW, Choi SW, Jo SM, Chin BD, Kim DY, Lee KY, J. Power Sources, 163(1), 41 (2006)
Kim C, J. Power Sources, 142(1-2), 382 (2005)
Pinto NJ, Johnson AT, MacDiarmid AG, Mueller CH, Theofylaktos N, Robinson DC, Miranda FA, Appl. Phys. Lett., 83, 4244 (2003)
Aussawasathien D, Dong JH, Dai L, Synthetic Met., 54, 37 (2005)
Jang SY, Seshadri V, Khil MS, Kumar A, Marquez M, Mather PT, Sotzing GA, Adv. Mater., 17(18), 2177 (2005)
Tan SH, Inai R, Kotaki M, Ramakrishna S, Polymer, 46(16), 6128 (2005)
Ziabicki A, Fundamentals of fiber formation: The science of fiber spinning and drawing, Wiley, New York (1976)
Podgorski A, Balazy A, Gradon L, Chem. Eng. Sci., 61(20), 6804 (2006)
Ding B, Yamazaki M, Shiratori S, Sens. Actuators B, 106, 477 (2005)
Kim JR, Choi SW, Jo SM, Lee WS, Kim BC, Electrochim. Acta, 50(1), 69 (2004)
Moroni L, Licht R, de Boer J, de Wijn JR, van Blitterswijk CA, Biomaterials, 27, 4911 (2006)
Wang T, Kumar S, J. Appl. Polym. Sci., 102(2), 1023 (2006)
Cui WG, Li XH, Zhou SB, Weng J, J. Appl. Polym. Sci., 103(5), 3105 (2007)
Sukigara S, Gandhi M, Ayutsede J, Micklus M, Ko F, Polymer, 45(11), 3701 (2004)
Gu SY, Ren J, Vancso GJ, Eur. Polym. J., 41, 2559 (2005)
Gu SY, Ren J, Macromol. Mater. Eng., 290, 1097 (2005)
Yordem OS, Papila M, Menceloglu YZ, Mater. Design, 29, 34 (2008)
Sakurada I, Polyvinyl alcohol fibers, CRC, New York (1985)
Marten FL, Vinyl alcohol polymers, in: Mark HF (Ed.), Encyclopedia of polymer science and technology, 3rd ed., vol. 8, Wiley (2004)
Kwon YD, Kavesh S, Prevorsek DC, U.S. Patent, 4,440,711 (1984)
Kavesh S, Prevorsek DC, U.S. Patent, 4,551,296 (1985)
Tanaka H, Suzuki M, Uedo F, U.S. Patent, 4,603,083 (1986)
Paradossi G, Cavalieri F, Chiessim E, Spagnoli C, Cowman MK, J. Mater. Sci.: Mater. Med., 14, 687 (2003)
Zheng-Qiu G, Jiu-Mei X, Xiang-Hong Z, Biomed. Mater. Eng., 8, 75 (1998)
Oka M, Ushio K, Kumar P, Ikeuchi K, Hyon SH, Nakamura T, Fujita H, P. I. Mech. Eng. H, 214, 59 (2000)
Burczak K, Gamian E, Kochman A, Biomaterials, 17, 2351 (1996)
Li JK, Wang N, Wu XS, J. Control. Release, 56, 117 (1998)
Hoffman AS, Adv. Drug Delivery Rev., 43, 3 (2002)
Zeng J, Aigner A, Czubayko F, Kissel T, Wendorff JH, Greiner A, Biomacromolecules, 6(3), 1484 (2005)
Hong KH, Polym. Eng. Sci., 47(1), 43 (2007)
Ziabari M, Mottaghitalab V, Haghi AK, Korean J. Chem. Eng., 25(4), 919 (2008)
Ziabari M, Mottaghitalab V, Haghi AK, Braz. J. Chem. Eng., 26, 53 (2009)
Ziabari M, Mottaghitalab V, McGovern ST, Haghi AK, Nanoscale Res. Lett., 2, 597 (2007)
Ziabari M, Mottaghitalab V, Haghi AK, Korean J. Chem. Eng., 25(4), 905 (2008)
Sperling LH, Introduction to physical polymer science, 4th ed., Wiley, New Jersey (2006)
Tacx JCJF, Schoffeleers HM, Brands AGM, Teuwen L, Polymer, 41(3), 947 (2000)
Ko FK, Nanofiber technology, in: Gogotsi Y (Ed.), Nanomaterials handbook, CRC, Boca Raton (2006)
Koski A, Yim K, Shivkumar S, Mater. Lett., 58, 493 (2004)
Montgomery DC, Design and analysis of experiments, 5th ed., Wiley, New York (1997)
Dean A, Voss D, Design and analysis of experiments, Springer, New York (1999)
Box GEP, Draper NR, Response surfaces, mixtures, and ridge analyses, Wiley, New Jersey (2007)
Carley KM, Kamneva NY, Reminga J, Response surface methodology, CASOS Technical Report, CMU-ISRI-04-136 (2004)
Weisberg S, Applied linear regression, 3rd ed., Wiley, New Jersey (2005)
Zhang C, Yuan X, Wu L, Han Y, Sheng J, Eur. Polym. J., 41, 423 (2005)
Li Q, Jia Z, Yang Y, Wang L, Guan Z, Preparation and properties of poly(vinyl alcohol) nanofibers by electrospinning, Proceedings of IEEE International Conference on Solid Dielectrics, Winchester, U.K. (2007)
Mit-uppatham C, Nithitanakul M, Supaphol P, Macromol. Chem. Phys., 205, 2327 (2004)
Ryu YJ, Kim HY, Lee KH, Park HC, Lee DR, Eur. Polym. J., 39, 1883 (2003)
Jarusuwannapoom T, Hongrojjanawiwat W, Jitjaicham S, Wannatong L, Nithitanakul M, Pattamaprom C, Koombhongse P, Rangkupan R, Supaphol P, Eur. Polym. J., 41, 409 (2005)
Baker SC, Atkin N, Gunning PA, Granville N, Wilson K, Wilson D, Southgate J, Biomaterials, 27, 3136 (2006)
Sukigara S, Gandhi M, Ayutsede J, Micklus M, Ko F, Polymer, 44(19), 5721 (2003)
Yuan X, Zhang Y, Dong C, Sheng J, Polym. Int., 53, 1704 (2004)
Ki CS, Baek DH, Gang KD, Lee KH, Um IC, Park YH, Polymer, 46(14), 5094 (2005)
Deitzel JM, Kleinmeyer J, Harris D, Tan NCB, Polymer, 42(1), 261 (2001)
Buchko CJ, Chen LC, Shen Y, Martin DC, Polymer, 40(26), 7397 (1999)
Lee JS, Choi KH, Do Ghim H, Kim SS, Chun DH, Kim HY, Lyoo WS, J. Appl. Polym. Sci., 93(4), 1638 (2004)
Fennessey SF, Farris RJ, Polymer, 45(12), 4217 (2004)
Kidoaki S, Kwon IK, Matsuda T, Biomaterials, 26, 37 (2005)
Zong XH, Kim K, Fang DF, Ran SF, Hsiao BS, Chu B, Polymer, 43(16), 4403 (2002)
Li D, Xia Y, Nano. Lett., 3, 555 (2003)
Jin WZ, Duan HW, Zhang YJ, Li FF, Nonafiber membrane of EVOH-based ionomer by electrospinning, Proceedings of the 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Zhuhai, China (2006)
Mo XM, Xu CY, Kotaki M, Ramakrishna S, Biomaterials, 25, 1883 (2004)
Zhao SL, Wu XH, Wang LG, Huang Y, J. Appl. Polym. Sci., 91(1), 242 (2004)