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Received April 7, 2010
Accepted April 20, 2010
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Polymeric nanoparticles, micelles and polymersomes from amphiphilic block copolymer
Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Korea 1Department of Chemical Engineering, Stanford University, Stanford, CA 94305, United States, USA 2Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea
inwoo@knu.ac.kr
Korean Journal of Chemical Engineering, March 2010, 27(3), 731-740(10), 10.1007/s11814-010-0216-5
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Abstract
Block copolymers are made up of blocks of different polymerized monomers. Among the block copolymers, amphiphilic block copolymers can self-assemble to form nano-sized vehicles, such as micelles, nanoparticles, polymersomes, in aqueous or non-aqueous media. This review describes the synthesis, formation, and major applications of amphiphilic block copolymer and corresponding vehicles in order to provide an overview of the current features of functionalized block copolymers for drug delivery applications.
Keywords
References
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Muhlebach A, Gaynor SG, Matyjaszewski K, Macromolecules, 31(18), 6046 (1998)
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Jia ZF, Wong LJ, Davis TP, Bulmus V, Biomacromolecules, 9(11), 3106 (2008)
Stenzel Martina H, Barner-Kowollik C, Davis Thomas P, Dalton Helen, M, Macromol. Biosci., 4, 445 (2004)
Schilli CM, Zhang MF, Rizzardo E, Thang SH, Chong YK, Edwards K, Karlsson G, Muller AHE, Macromolecules, 37(21), 7861 (2004)
Sumerlin BS, Donovan MS, Mitsukami Y, Lowe AB, McCormick CL, Macromolecules, 34(19), 6561 (2001)
Sumerlin BS, Lowe AB, Thomas DB, McCormick CL, Macromolecules, 36(16), 5982 (2003)
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Zhang LF, Eisenberg A, J. Am. Chem. Soc., 118(13), 3168 (1996)
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