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Received July 23, 2009
Accepted September 27, 2009
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Application of gas anti-solvent process to the recovery of andrographolide from Andrographis paniculatanees
Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900, Thailand
manop.c@ku.ac.th
Korean Journal of Chemical Engineering, March 2010, 27(3), 950-954(5), 10.1007/s11814-010-0128-4
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Abstract
The gas anti-solvent (GAS) process was employed to extract andrographolide, which is the active ingredient found in Andrographis Paniculatanees, using carbon dioxide as an anti-solvent. The effects of temperature, flow rate and solvent type on the extraction recovery, particle size and morphology were investigated in this study. The experiments were conducted at the temperature ranging from 25-45 ℃, carbon dioxide flow rate of 1-15 mL/min, and various types of organic solvents (methanol, ethanol, acetone and N,N-dimethylformamide). The extracted product was analyzed using high performance liquid chromatography (HPLC). The highest extraction yield was found to be 1.24 g andrographolide per 100 g of A. paniculata when using acetone as a solvent, carbon dioxide flow rate of 5 mL/min and the temperature of 35 ℃. It was also found that no significant change in size or morphology of the precipitates was observed when changing temperature, carbon dioxide flow rate and solvents.
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Calabrese C, Berman SH, Babish JG, Ma X, Shinto L, Dorr M, Wells K, Wenner CA, Standish LJ, Phytother. Res., 14, 333 (2000)
Kumoro AC, Hasan M, Chin. J. Chem. Eng., 15(6), 877 (2007)
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Thiering R, Dehghani F, Dillow A, Foster NR, J. Chem. Technol. Biotechnol., 75(1), 29 (2000)
