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Received April 14, 2010
Accepted June 8, 2010
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Recent advances in bioreactor engineering
1Key Laboratory of Microbial Metabolism (MOE), School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China 2State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
jjzhong@sjtu.edu.cn
Korean Journal of Chemical Engineering, July 2010, 27(4), 1035-1041(7), 10.1007/s11814-010-0277-5
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Abstract
A bioreactor is the core of biological processes. To design an appropriate bioreactor system for a particular bioprocess, intensive studies on the biological system, such as cell growth, metabolism, genetic manipulation, and protein or other product expression are needed to understand the cells’ requirement on their physical and chemical environments. It is also necessary to control and optimize the bioreactor environment via operating variables in order to_x000D_
favor the desired functions of cells and achieve cost-effective large-scale manufacture. This article briefly describes fundamental design principles and new types of bioreactors such as centrifugal impeller and wave bioreactors. Bioreactor operation factors and modes including mixing, oxygen supply, shear force, fed-batch, and perfusion cultures are discussed. The trends in bioreactor engineering are also briefly shown.
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Yokoi H, Koga J, Yamamura K, Seike Y, Tanaka H, J. Ferment. Bioeng., 75, 48 (1993)
Ogbonna JC, Yada H, Masui H, Tanaka H, J. Ferment. Bioeng., 82(1), 61 (1996)
Cheng JY, Carreau PJ, Can. J. Chem. Eng., 72(3), 418 (1994)
Kamen AA, Tom RL, Caron AW, Chavarie C, Massie B, Archambault J, Biotechnol. Bioeng., 38, 619 (1991)
Wang SJ, Zhong JJ, Biotechnol. Bioeng., 51(5), 511 (1996)
Butler M, Appl. Microbiol. Biotechnol., 68(3), 283 (2005)
Kretzmer G, Appl. Microbiol. Biotechnol., 59(2-3), 135 (2002)
Singh V, Cytotechnology., 30, 149 (1999)
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Jordan M, Sucker H, Einsele A, Widmer F, Eppenberger HM, Biotechnol. Bioeng., 43(6), 446 (1994)
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Boulton-Stone JM, Blake JR, J. Fluid Mech., 302, 231 (1993)
Zhong JJ, Fujiyama K, Seki T, Yoshida T, Biotechnol. Bioeng., 44(5), 649 (1994)
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Cherry RS, Hull CT, Biotechnol. Prog., 8, 11 (1992)
Handa-Corrigan AN, Emery AN, Spier RE, Enzyme Microb. Technol., 11, 230 (1989)
Jobses I, Martens D, Tramper J, Biotechnol. Bioeng., 37, 484 (1991)
Chisti Y, Crit. Rev. Biotechnol., 21, 67 (2001)
Wang SJ, Zhong JJ, Biotechnol. Bioeng., 51(5), 511 (1996)
Wang SJ, Zhong JJ, Biotechnol. Bioeng., 51(5), 520 (1996)
Huang T, Wang P, Wu W, Biochem. Eng. J., 7, 35 (2001)
Mang ZY, Zhong JJ, Biotechnol. Prog., 20(4), 1076 (2004)
Zhong JJ, J. Biosci. Bioeng., 94(6), 591 (2002)
Zhong JJ, Pan ZW, Wang ZY, Wu JY, Chen F, Takagi M, Yoshida T, J. Biosci. Bioeng., 94(3), 244 (2002)
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Wu J, Ho K, Appl. Biochem. Biotechnol., 82(1), 17 (1999)
Wang HQ, Yu JT, Zhong JJ, Process Biochem., 35, 479 (1999)
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Jardin BA, Montes J, Lanthler S, Tran R, Elias C, Biotechnol. Bioeng., 97(2), 332 (2007)
Deo YM, Mahadevan MD, Fuchs R, Biotechnol. Prog., 12(1), 57 (1996)
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Chen A, Chitta R, Chang D, Anianullah A, Biotechnol. Bioeng., 102(1), 148 (2009)
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Patil KR, Akesson M, Nielsen J, Curr. Opinion Biotechnol., 15, 64 (2004)
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Nielsen J, Olsson L, FEMS Yeast Res., 2, 175 (2002)
Verpoorte R, van der Heijden R, Memelink J, Transgenic Res., 9, 323 (2000)
Oksman-Caldentey KM, Inze D, Trends Plant Sci., 9, 433 (2004)
Hellwig S, Drossard J, Twyman RM, Fischer R, Nat. Biotechnol., 22, 1415 (2004)
Wang W, Ph.D. thesis, ECUST, Shanghai (2004)
