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Received March 15, 2010
Accepted March 28, 2010
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Surface functionalization of SBA-15 particles for ibuprofen delivery
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea 1New & Renewable Energy Division, Korea Institute of Energy Technology Evaluation & Planning, Seoul 135-280, Korea
Korean Journal of Chemical Engineering, July 2010, 27(4), 1087-1092(6), 10.1007/s11814-010-0225-4
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Abstract
We have synthesized SBA-15 particles and functionalized their surface with different functional groups (amine, diamine, and sulfonic acid groups) to use them as carrier materials in drug delivery. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen sorption, and zeta potential measurements were used to characterize the synthesized particles. After surface functionalization, the surface of the sulfonic acid-functionalized particles was more acidic than that of the other particles. Using ibuprofen as a model drug, we found that the release rate increased at higher pH. Furthermore, the particles with the sulfonic acid groups exhibited higher release rate than those with the amine and diamine groups. We explained the difference in the release rate using different electrostatic interaction between drug and particle surface that was caused by the surface functionalization. These results should enable design of drug carrier materials based on the SBA-15 particles with the desired release rate.
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Yakovlev GA, Biomed. Eng., 38, 292 (2004)
Lonnerdal B, J. Am. Coll. Nutr., 21, 218S (2002)
