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Received February 19, 2010
Accepted March 24, 2010
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Micronization and characterization of drug substances by RESS with supercritical CO2
Department of Chemical Engineering, Pukyong National University, Busan 608-739, Korea
csju@pknu.ac.kr
Korean Journal of Chemical Engineering, July 2010, 27(4), 1139-1144(6), 10.1007/s11814-010-0219-2
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Abstract
A RESS (rapid expansion of supercritical solution) process for the preparation of ultra-fine drug particles with no organic solvent has been developed with supercritical CO2. Three drug substances with different solubility in supercritical CO2 were used, and orifice disks and capillary tubes were adapted as an expansion device. The solubilities of drug substances in supercritical CO2 and the effects of various operating parameters on the characteristics of the particles prepared by RESS process were experimentally investigated. The solubility of the drug substance in supercritical CO2 had a major effect on the average diameter of the particle prepared by RESS process, and the particle diameter decreased with the solubility for all the drugs and operating conditions. The particle diameter also decreased with preexpansion_x000D_
temperature and increased with the hole diameter of the orifice nozzle and aspect ratio (L/D) of the capillary tube.
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