Articles & Issues

Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received September 24, 2009
Accepted November 11, 2009

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

All issues

Comparison of amine-functionalized mesoporous silica particles for ibuprofen delivery

Kitae Lee¹ Deokkyu Lee¹ Hosub Lee¹ Chang-Koo Kim² Zhijian Wu^{3 4} Kangtaek Lee^1†

¹Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea ²Department of Chemical Engineering and Division of Energy Systems Research, Ajou University, Suwon 442-749, Korea ³Key Laboratory of Salt Lake Resources and Chemistry, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008, China ⁴The Key Laboratory for Functional Materials of Fujian Higher Education, Huaqiao University, Quanzhou 362021, China

Korean Journal of Chemical Engineering, July 2010, 27(4), 1333-1337(5), 10.1007/s11814-010-0179-6

Download PDF

Abstract

We have prepared three different types of amine-functionalized silica particles: i) mesoporous silica (MESO1); ii) nonporous core-mesoporous shell silica (MESO2); iii) SBA-15 particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen sorption experiment were used to study the morphology of the synthesized particles. To investigate the drug loading and subsequent release of the particles, ibuprofen was used_x000D_ as a model drug for oral delivery. Loading capacity of the particles in this work was found to be higher than that in the previous studies, and followed the order of MESO1>MESO2>SBA-15 particles. Release experiments showed the similar release rate for MESO1 and MESO2 particles from which only <40% of ibuprofen was released after 5 h. From SBA-15 particles, however, more than 80% of ibuprofen was released in 5 h at pH 4 and 7.4. Ibuprofen release from SBA-15 was slowest at pH 2 (~pH of stomach body) and fastest at pH 7.4 (~pH of proximal intestine). Difference in release rates was ascribed to the different morphology and pore structure of the carrier particles.

Keywords

Mesoporous Silica Ibuprofen Loading Release

References

Qu F, Zhu G, Lin H, Sun J, Zhang D, Li S, Qiu S, Eur. J.Inorg. Chem., 2006, 3943 (2006)
Vallet-Regi M, Balas F, Arcos D, Angew.Chem. Int. Ed., 46, 7548 (2007)
Wu Z, Jiang Y, Kim T, Lee K, J. Control. Release., 119, 215 (2007)
Manzano M, Aina V, Arean CO, Balas F, Cauda V, Colilla M, Delgado MR, Vallet-Regi M, Chem. Eng. J., 137(1), 30 (2008)
Lai CY, Trewyn BG, Jeftinija DM, Jeftinija K, Xu S, Jeftinija S, Lin VSY, J. Am. Chem. Soc., 125(15), 4451 (2003)
Qu F, Zhu G, Lin H, Zhang W, Sun J, Lia S, Qiu S, J. Solid State Chem., 179, 2027 (2006)
Xu WJ, Gao Q, Xu Y, Wu D, Sun YH, Shen WF, Deng F, Powder Technol., 191(1-2), 13 (2009)
Xu W, Gao Q, Xua Y, Wu D, Sun Y, Shen W, Deng F, J. Solid State Chem., 181, 2837 (2008)
Yoon SB, Kim JB, Kim JH, Park YJ, Yoon KR, Park SK, Yu JS, J. Mater. Chem., 17, 1758 (2007)
Zhao DY, Feng JL, Huo QS, Melosh N, Fredrickson GH, Chmelka BF, Stucky GD, Science, 279(5350), 548 (1998)
Brodie-Linder N, Dosseh G, Alba-Simonesco C, Audonnet F, Imperor-Clerc M, Mater. Chem. Phys., 108(1), 73 (2008)
Doadrio JC, Sousa EMB, Izquierdo-Barba I, Doadrio AL, Perez-Pariente J, Vallet-Regi M, J. Mater. Chem., 16, 462 (2006)
Huh S, Wiench JW, Yoo JC, Pruski M, Lin VSY, Chem.Mater., 15, 4247 (2003)
Barbe C, Bartlett J, Kong LG, Finnie K, Lin HQ, Larkin M, Calleja S, Bush A, Calleja G, Adv. Mater., 16(21), 1959 (2004)
Vallet-Regi M, Ramila A, del Real RP, Perez-Pariente J, Chem.Mater., 13, 308 (2001)
Yakovlev G, Biomed. Eng., 38, 292 (2004)
Lonnerdal B, J. Am. Coll. Nutr., 21, 218S (2002)