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Received May 7, 2010
Accepted June 6, 2010
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Determination of optimum fermentation conditions for carotenoid production by Rhodotorula aurantiaca K-505
Mogam Biotechnology Research Institute, Gyeonggi 446-799, Korea 1Department of Chemical Engineering, Xi’an Jiaotong University, Xi’an 710049, China 2Department of Chemical Engineering, The University of Seoul, Seoul 130-743, Korea
Korean Journal of Chemical Engineering, January 2011, 28(1), 216-220(5), 10.1007/s11814-010-0346-9
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Abstract
Carotenoid production by Rhodotorula aurantiaca K-505 was optimized in shake-flask cultures using a central composite design. Quadratic polynomial models were used to correlate the relationships between six fermentation factors (pH, temperature, and the concentrations of glucose, yeast extract, peptone extract, and ammonium sulfate) and three response variables (cell mass yield, carotenoid content, and carotenoid production). Different optimum culture_x000D_
conditions were predicted by the models for maximizing the three response variables, indicating that there is no direct correlation between cell growth and carotenoid production. The maximum carotenoid production of 4.9 mg/L predicted by the relevant model under optimum culture conditions agreed well with the experimentally measured value of 5.3 mg/L under the same culture conditions.
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