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Received November 11, 2010
Accepted March 29, 2011
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Protective effect of nicotinic acid on human albumin during UV-C irradiation
Department of Chemical Engineering, La Sapienza University, Via Eudossiana 18, Rome 00184, Italy
roberto.lavecchia@uniroma1.it
Korean Journal of Chemical Engineering, October 2011, 28(10), 1965-1968(4), 10.1007/s11814-011-0083-8
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Abstract
The potential of nicotinic acid (NiAc), a vitamin B3 compound with antioxidant activity, to protect human albumin against the damage caused by exposure to 254-nm UV-C radiation was investigated. Experiments performed at irradiance levels of 3.5-15 W m^(-2) and application times between 5 and 30 min showed that albumin undergoes rapid dose-dependent aggregation when subjected to irradiation. Addition of 0.2 mM NiAc to the albumin solution resulted in a remarkable reduction of protein damage. Protection provided by NiAc was effective up to radiation doses of about 30 kJ m^(-2), which are significantly higher than those required for complete microbial and viral inactivation.
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