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Received January 6, 2011
Accepted May 5, 2011
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Evaluation of the reducing power effect on the enantioselective synthesis of methyl (R)-2-chloromandelate using Saccharomyces cerevisiae
Department of Chemical Engineering & Bioengineering, University of Ulsan, Daehakro 93, Nam-gu, Ulsan 680-749, Korea 1School of Chemical & Biomolecular Engineering, Dongyang University, 1 Kyochon, Pungki-eup, Youngju 750-711, Korea
shhong@ulsan.ac.kr
Korean Journal of Chemical Engineering, December 2011, 28(12), 2316-2318(3), 10.1007/s11814-011-0124-3
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Abstract
The effect of the reducing power on the reduction of methyl-2-chlorobenzoylformate was evaluated by using carbon substrates with different reducing powers. Glucose, sorbitol, and gluconate regenerated 2, 3, and 1 NAD(P)H during its conversion to pyruvate, respectively. When sorbitol was used as the carbon substrate, complete conversion was achieved in 8 h while it took 12 h and 19 h when glucose and gluconate were used, respectively. The enantiomeric excess (ee) value was 96.7% when sorbitol was used.
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