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Received January 13, 2010
Accepted February 21, 2010
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Retention mechanism of some solutes using ionic liquids as mobile phase modifier in RP-high-performance liquid chromatography (HPLC)
Department of Chemical Engineering, Inha University, 253, Yonghyun-dong, Nam-gu, Incheon 402-751, Korea
rowkho@inha.ac.kr
Korean Journal of Chemical Engineering, February 2011, 28(2), 357-363(7), 10.1007/s11814-010-0273-9
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Abstract
Two kinds of ionic liquid, 1-Hexyl-3-methylimidazolium tetrafluoroborate ([Hmim][BF4]) and 1-Methyl-3-octylimidazolium tetrafluoroborate ([Omim][BF4]), were used as additives in the linear solvation energy relationships (LSERs) model to investigate the fundamental chemical interactions governing the retention of nine aromatic compounds in acetonitrile/water mobile phases on a C18 column. The effects of the [Hmim][BF4] and [Omim][BF4] were compared and the ability of the LSERs to account for the chemical interactions underlying solute retention was shown. A comparison of predicted and experimental retention factors suggests that LSER formalism is able to reproduce adequately the experimental retention factors of the solutes studied in the different experimental conditions investigated.
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