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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received August 23, 2023
Accepted August 23, 2023

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Profiling of skin anti-aging related proteins in human dermal fibroblasts by decursin in Angelica gigas Nakai

Mi Ae Yoo¹ Young Keun Song¹ Hyein Jang^{1 2} Dong Myung Kim^{3 4} Sang Yo Byun^1†

¹Head of Cosmetic Science Major, Applied Biotechnology Program, Graduate School, Ajou University, Wonchon-dong, Youngtong-gu, Suwon, Gyunggi-do 442-749, Korea ²Univera, Sungsu-dong, Sungdong-gu, Seoul 133-120, Korea ³*Head of Cosmetic Science Major, Applied Biotechnology Program, Graduate School, Ajou University, Wonchon-dong, Youngtong-gu, Suwon, Gyunggi-do 442-749, Korea ⁴Kolmar Korea, Chonui Myun, Yunki Gun, Chunganm-do 339-851, Korea

Korean Journal of Chemical Engineering, March 2011, 28(3), 880-885(6), 10.1007/s11814-010-0430-1

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Abstract

The extract of Angelica gigas Nakai by supercritical CO2 increased the expression of collagen synthesisrelated proteins in human dermal fibroblast, including type 1(α-2) collagen chain precursor (pI 9.08, MW 129.7), procollagen C-endopeptidase (pI 7.40, MW 47.97), and prolyl 4-hydroxylase (pI 5.49, MW 60.90). It also increased the expression level of interaction-related proteins, α-actinin (pI 5.47, MW 105.5), integrin-β1 (pI 5.27, MW 88.46). The expression levels of these proteins by pure decursin were similar to those by supercritical fluid extract. By the dose_x000D_ concentration experiment, decursin in A. gigas was found to play the major role in expression level increases. Proteome analysis proved that decursin in A. gigas promoted synthesis of proteins related to skin anti-aging in human dermal fibroblasts.

Keywords

Desursin Angelica gigas Nakai Skin Anti-aging Collagen Synthesis

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