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Received August 23, 2023
Accepted August 23, 2023
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Potential application of acetone extract of Astragalus sinicus Linne seed to functional cosmetics
1Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea 2Biotechnology Lab, BK Company R&D Center, Jeonbuk 579-879, Korea 3Department of Environmental Health, Chodang University, Jeonnam 534-800, Korea 4Department of Health Sciences, Chosun University, Gwangju 501-759, Korea 5Department of Cosmetics, Cheongam University, Jeonnam 540-743, Korea 6Department of Herb Therapy, Wonkwang Health Science University, Jeonbuk 570-750, Korea
ran2654@hanmail.net
Korean Journal of Chemical Engineering, March 2011, 28(3), 890-894(5), 10.1007/s11814-010-0510-2
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Abstract
For the functional cosmetic agent using acetone extract of A. sinicus Linne seed, the effects of whitening, wrinkling, and safety were investigated. Cell viabilities of Raw 264.7 up to 60 mg/mL did not appear to have any significant direct cytotoxic effect. The melanin concentration was decreased up to 62.1% at 20 mg/mL. When the acetone extract concentration of A. sinicus Linne seed was increased from 5 to 20 mg/mL, the inhibitory activity of tyrosinase was sharply increased from 61.3 to 93.8%. However, above 30 mg/mL, it did not increase. The inhibition effects of elastase and collagenase were increased with the extract concentration. Especially, when acetone extract concentration of A. sinicus Linne seed was increased from 25 to 200 μg/mL, the inhibition effect of elastase was increased from 60.2 to 97.5%. The inhibition effect of collagenase was increased from 35.0 to 99.0% when increased from 50 to 300 μg/mL. The indexes of pigment and coarseness were 28.56 MI and 18.45R-value, respectively, after 8 weeks of clinical trial using cream pack containing 0.2% of acetone extract of A. sinicus Linne seed. The indexes of elasticity and moisture were 64.5Ur/Uf and 55.2AU, respectively, after 8 weeks of clinical trial. These results demonstrate that acetone extract of A. sinicus Linne seed may be useful as a potential agent for functional cosmetics.
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Choi DB, Lee KI, Kim NY, Kim R, Kor. Soci. Aest. Costmet., 7, 217 (2009)
Rescigno A, Sollai F, Pisu B, Rinaldi A, Sanjust E, J. Enzym. Inhibi. Med. Chem., 17, 207 (2002)
An BJ, Kwak JH, Park JM, Lee JY, Park TS, Lee JT, Son JH, Jo C, Byun MW, Phy. Res., 17, 987 (2005)
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Ha BC, Cosmeceuticals., Shin Kwang Publishing, Seoul (2005)
Elsner P, Mailbach HI, Cosmeceuticals and active cosmetics., 2nd Ed., Taylor & Francis, New York (2005)
