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- In relation to this article, we declare that there is no conflict of interest.
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Received June 2, 2010
Accepted October 14, 2010
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Identification of depigmenting components from Nigella glandulifera Freyn
Department of Biological Engineering, National Research Lab of Skinbioactive Materials, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon 402-751, Korea
ekkim@inha.ac.kr
Korean Journal of Chemical Engineering, April 2011, 28(4), 1070-1073(4), 10.1007/s11814-010-0457-3
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Abstract
To develop a novel skin depigmenting agent from natural sources, the inhibition of melanogenesis by Chinese plants, N. glandulifrea, was evaluated. The methanol extract of this plant showed significantly down-regulated melanin synthesis in a dose-dependent manner at a non-toxic concentration in cultured B16F10 mouse melanoma cells. This extract was further fractionated by using solvent-solvent partition and silica open column chromatography to identify_x000D_
the active components. From GC-MS data, oleic acid methyl ester was found as one of the depigmenting agents. In conclusion, we suggest that this fraction may be a safe and effective depigmentation agent.
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References
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