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Received January 13, 2011
Accepted March 2, 2011
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The principles and applications of nano-diagnosis system for a nano-biosensor
Department of Chemical Engineering, Dong-A University, 840 hadan-dong, Saha-gu, Busan 604-714, Korea 1Department of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1, Katakura, Hachioji, Tokyo 192-0982, Japan
karube@bs.teu.ac.jp
Korean Journal of Chemical Engineering, April 2011, 28(4), 987-1008(22), 10.1007/s11814-011-0051-3
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Abstract
In this review, the basic principles and research trends of biosensors are briefly described and a nano-sensing system applying QCM (quartz crystal micro-balance), nano-diagnosis methods by AFM (atomic force microscopy) and SNOAM (scanning near-field/atomic force microscopy) is discussed intensively. The principle, construction, and applications of piezoelectric crystal sensors as a universal sensor are reviewed. This review is focused mainly on liquid phase applications, such as immune-sensors, gelation detecting sensors, and cultured cell monitoring sensors. The principle of nano-diagnosis based on the AFM or SNOAM techniques is described in detail. Finally, the binding affinity of peptide probes to proteins using AFM and the visualizing of a hybridized PNA probe on a DNA molecule using SNOAM are evaluated and discussed.
Keywords
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