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Received July 7, 2010
Accepted November 19, 2010
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Kinetics and optimization of L-tryptophan separation with ion-exchange chromatography
Institute of Bioengineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China 1School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310012, China 2Zhejiang University City College, Hangzhou 310015, China
lhuangblue@zju.edu.cn
Korean Journal of Chemical Engineering, May 2011, 28(5), 1280-1285(6), 10.1007/s11814-010-0489-8
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Abstract
Adsorption and desorption of L-tryptophan (L-trp) on strong acid cation exchange resin were investigated in a fixed-bed column. L-trp was effectively adsorbed onto the resin HZ-001, with the loading capacity and breakthrough time determined. Four kinetic models, including Adams-Bohard, Wolborska, Thomas, and Yoon-Nelson models, were adopted to determine the kinetic parameters of adsorption and to predict the breakthrough curves. The results showed that the models used described the breakthrough well. Desorption of L-trp from the column bed was performed using aqueous ammonia as the eluant. Optimum procedure was obtained with 2.0M aqueous ammonia at the elution velocity of 6 BV/h. Five cycles of adsorption-elution-regeneration were conducted to evaluate the column reutilization.
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