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Received May 2, 2011
Accepted May 19, 2011
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Engineering molecularly imprinted polymer (MIP) materials: Developments and challenges for sensing and separation technologies
Department of Chemistry and Department of Chemical and Biomolecular Engineering, University of Houston, 136 Fleming Bldg. Houston, Texas 77204, USA
radvincula@uh.edu
Korean Journal of Chemical Engineering, June 2011, 28(6), 1313-1321(9), 10.1007/s11814-011-0133-2
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Abstract
Molecular imprinting, artificial receptors, plastic antibodies are terms associated with synthetic materials capable of chemical and biological sensing. Through the years, these sensors have advanced greatly not only in analytical chemistry; they have high utility for environmental, health, security, military, etc. monitoring and separations applications. New transduction methods and miniaturization have enabled in-situ and real-time sensing capabilities. On the other hand, they have high utility as matrices for chemical and biological separations. The challenge of employing_x000D_
molecularly imprinted polymers or MIPs as receptors lie in demonstrating high selectivity and sensitivity. Robustness and cost are also important considerations. Traditional methods of monolith polymerization employing free radical polymerization mechanisms have yielded good performance but lack the ability to demonstrate repeatable selectivity and sensitivity. Thin films have been deemed to be more useful in sensing applications, but may not offer the right throughput for separations applications. Engineering optimized materials require not only adapting to new chemistries but also knowing their structure-property relationships.
Keywords
References
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Byrne M, Park K, Peppas N, Advanced Drug Delivery Reviews., 54, 149 (2002)
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Warriner K, Lai E, Namvar A, Hawkins D, Reddy S, Molecular imprinted polymers for biorecognition of bioagents, Principles of Bacterial Detection: Biosensors, Recognition Receptors, and Microsystems., 3, 785 (2008)
Byrne M, Saliana V, Int. J. Pharmaceutics., 364, 188 (2008)
Taranekar P, Baba A, Park JY, Fulghum TM, Advincula R, Adv. Funct. Mater., 16(15), 2000 (2006)
Apodaca D, Pernites R, Ponnapati R, Del Mundo F, Advincula R, ACS Applied Materials and Interfaces., 3(2), 191 (2011)
