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Received November 18, 2010
Accepted January 29, 2011
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Recombinant protein secretion via the type III secretion system
Department of Chemical Engineering & Bioengineering, University of Ulsan, Daehak-ro 93, Nam-gu, Ulsan 680-749, Korea
shhong@ulsan.ac.kr
Korean Journal of Chemical Engineering, July 2011, 28(7), 1573-1579(7), 10.1007/s11814-011-0024-6
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Abstract
The type III secretion system (T3SS) is a mechanism by which bacteria export proteins from the cytoplasm, through the membranes, to the extracellular environment. T3SS is made up of more than 20 different proteins, about half of which maintain conserved sequences. This review summarizes the features of this novel apparatus and discusses the potential of utilizing T3SS to export recombinant proteins into the external environment, and the impact this system will have on protein production technology.
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