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Received November 15, 2010
Accepted March 13, 2011
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Modeling and simulation of tanks-in-series airlift bioreactors for production of lactic acid by fermentation
Chemical and Environmental Engineering Group, Islamic Azad University, South Tehran Branch, Tehran, Iran 1Chemical & Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran 2Biotechnology Group, Engineering Faculty, Azad University of Science & Research, Tehran, Iran 3Department of Chemical Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran
vafajoo@azad.ac.ir
Korean Journal of Chemical Engineering, August 2011, 28(8), 1727-1735(9), 10.1007/s11814-011-0062-0
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Abstract
A tanks-in-series model was applied for mathematical modeling of the unsteady state performance of 70 and 100 liters airlift bioreactor for the production of lactic acid by fermentation. A set of first-order differential equations for the material balances of micro-organism, substrate, product, and dissolved oxygen around hypothetically well mixed stages was solved simultaneously utilizing computer program in MATLAB. The kinetic model utilized considered the_x000D_
effect of two substrates (glucose and dissolved oxygen) on the growth rate. The effect of air velocity on the lactic acid production was investigated. Results of this model have been validated with experimental data.
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Pigache S, Trystram G, Dhoms P, Biotechnol. Bioeng., 39, 923 (1992)
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Jia XQ, Wen JP, Jiang Y, Liu XL, Feng W, Chem. Eng. Sci., 61(11), 3463 (2006)
Andre G, Robinson CW, Young MM, Chem. Eng. Sci., 38, 1845 (1983)
Miura S, Arimura T, Hoshino M, Kojima M, Dwiarti L, Okabe M, J. Biosci. Bioeng., 96(1), 65 (2003)
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Chisti Y, Airlift Bioreactors, Elsevier, London (1989)
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