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Received January 14, 2011
Accepted February 22, 2011
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Porcine amniotic fluid as possible antiwrinkle cosmetic agent
Department of Pharmaceutical Engineering, Inje University, Gimhae, Gyongnam 621-749, Korea 1Amaranth Cosmetics, 1534-2, Songjung-dong, Gangseo-gu, Busan 618-817, Korea
pedkim@inje.ac.kr
Korean Journal of Chemical Engineering, September 2011, 28(9), 1839-1843(5), 10.1007/s11814-011-0047-z
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Abstract
Porcine amniotic fluid was investigated for use as a functional cosmetic ingredient. From safety tests by MTT (5-diphenyltetrazolium bromide) assay, cell viability was above 90% for 50-1,000 μg/mL concentration and porcine amniotic fluid was safe for cosmetic ingredient. From stability tests, cream containing 1% porcine amniotic fluid maintained constant physical properties for color, pH and viscosity during 28 days, and porcine amniotic fluid was stable for a cosmetic agent. Efficacy tests were done for antiwrinkle (elastase inhibition and collagenase synthesis inhibition), whitening (tyrosinase inhibition and DOPA (3,4-Dihydroxy-L-phenyl-alanine) oxidation inhibition) and antioxidation. At 500 μg/mL concentration, elastase inhibition of porcine placenta amniotic fluid was 33%, whereas that of adenosine as reference was 14%. However, porcine amniotic fluid showed relatively insignificant effect on collagenase synthesis inhibition, whitening and antioxidation activity. From this study, porcine amniotic fluid showed potential for a future_x000D_
antiwrinkle cosmetic agent.
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Pillai R, Redmond M, Roding J, IFSCC., 8, 17 (2005)
Park JC, Herbal functional food, Hyoilbooks, Seoul (2007)
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Ozqenel GY, Samil B, Ozcan M, J. Hand Surgery., 26, 332 (2001)
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Lee KH, Park SN, J. Soc. Cosmet. Scientists Korea., 34, 25 (2008)
Kim MJ, Lim KR, Jung TK, Yoon KS, J. Soc. Cosmet. Scientists Korea., 33, 33 (2007)
Kim JY, Yang HJ, Lee KH, Jeon SM, Ahn YJ, Won BR, Park SN, J. Soc. Cosmet. Scientists Korea., 33, 165 (2007)
