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Received January 6, 2011
Accepted March 9, 2011
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Establishment of a solvent map for formation of crystalline and amorphous paclitaxel by solvent evaporation process
Department of Chemical Engineering, Kongju National University, Cheonan, Chungnam 330-717, Korea
Korean Journal of Chemical Engineering, September 2011, 28(9), 1918-1923(6), 10.1007/s11814-011-0060-2
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Abstract
This study intended to establish a solvent map for formation of crystalline and amorphous paclitaxel by a solvent evaporation process. Crystalline paclitaxel was produced by evaporation with polar solvents (acetone, acetonitrile, ethanol, isobutyl alcohol, methanol, methyl ethyl ketone, and n-butyl alcohol) having a polarity index above 4.00. On the other hand, amorphous paclitaxel was produced by evaporation with non-polar solvents (methylene chloride, n-butyl chloride, and toluene) having a polarity index of about 4.00 or lower. The formation of paclitaxel was very closely associated with the polarity index of the organic solvent used in the solvent evaporation process. In the case of crystalline paclitaxel, the higher the polarity index and the lower the viscosity of the organic solvent (n-butyl alcohol, methyl ethyl ketone, and acetonitrile), the higher the degree of crystallinity. In the case of amorphous paclitaxel, the shape and size of particles varied according to the solvent (methylene chloride, n-butyl chloride, and toluene) used in the solvent evaporation process.
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Ferreira V, Fernandez P, Melendez J, Cacho J, J. Chromatogr.A., 695, 41 (1995)
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Park HJ, Kim MS, Lee S, Kim JS, Woo JS, Park JS, Hwang SJ, Int. J. Pharm., 328, 152 (2007)
Sarkar M, Perumal O, Panchagnula R, Indian J. Pharm. Sci., 70, 619 (2008)
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Cho EB, Cho WK, Cha KH, Park JS, Int. J. Pharm., 396, 91 (2010)
Kim BS, Kim JH, Korean J. Chem. Eng., 26(4), 1090 (2009)
