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Received December 19, 2011
Accepted March 20, 2012
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Effect of antioxidant in an acute lung injury animal model
Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University, 664-14 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Korea 1Division of Chemical Engineering, Chonbuk National University, 664-14 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Korea
kgb70@jbnu.ac.kr
Korean Journal of Chemical Engineering, November 2012, 29(11), 1591-1596(6), 10.1007/s11814-012-0041-0
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Abstract
The objective of this study was to scrutinize the involvement of nitric oxide (NO) and the diagnosis of blood in ARDS in a rat model determined by the sequential exposure to lipopolysaccharide (LPS). Also, the present study was designed to evaluate the effects of taurine and dexamethasone on ARDS induced by LPS. Measurements of nitrite/nitrate were elevated in BAL of LPS challenged rats, indicative of an induction of the NO synthase. Taurine and dexamethasone abrogated the extent of endotoxin-induced ARDS, as evidenced by the decreases BAL nitrate/nitrite, BALF protein and lung pathology. T+L+D-group had higher PaO2 and lower PaCO2 values than L-group and T+Lgroup. But, ionized Ca2+ and Mg2+ both were not shown significant change. Also, T+L and T+L+D-group showed significant increase compared with L-group, but for the other side no significant difference was seen between T+L and T+L+D group. We suggest that taurine and dexamethasone may be a drug of choice for preventing ARDS.
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References
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Kim GB, Kim SJ, Hong CU, Kwon TK, Kim NG, Korean J. Chem. Eng., 22(4), 521 (2005)
Kim GB, Kim SJ, Kim MH, Hong CU, Kang HS, J. Membr. Sci., 326(1), 130 (2009)
Fein AM, Lippmann MA, Holtzman H, Eliraz A, Goldverg SK, Chest., 83, 40 (1983)
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Wheeler AP, Bernard GR, N. Engl. J. Med., 40, 7 (1999)
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Brigham ML, Meyrick B, Am. Rev. Respir. Dis., 133, 913 (1986)
Cope DK, Grimbert F, Downey JM, Taylor AE, Crit. Care.Med., 20, 1043 (1992)
Sturman JA, Hayes KC, Adv. Nutri. Res., 3, 231 (1980)
Jeon SH, Lee MY, Kim SJ, Joe SK, Kim GB, Kim IS, Kim NS, Hong CU, Kim SZ, Kim JS, Kang HS, Febs Lett., 581, 5929 (2007)
Bernard GR, Am. J. Med., (Suppl.), 91, S54 (1991)
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Stapleton PP, O’Flaherty L, Redmond HP, Bouchier-Hayes DJ, J. Parenter. Enteral. Nutr., 22, 42 (1998)
Gurujeyalakshmi G, Wang Y, Giri SN, Nitric Oxide., 4, 399 (2000)
Elin RJ, Hristova EN, Cecco SA, Niemela JE, Rehak NN, Scand. J. Clin. Lab. Invest., 56, 203 (1999)
Cortijo J, Marti-Cabrera M, de la Asuncion JG, Pallardo FV, Esteras A, Bruseghini L, Vina J, Morcillo EJ, Free Radical Biol.Med., 27, 392 (1992)
Kao SJ, Wang D, Kin H, Chen HI, Clin. Exp. Pharmacol.P., 33, 33 (2006)
Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R, Am. J. Respir. Crit. Care. Med., 149, 818 (1994)
Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W, J. Biol. Chem., 267, 5317 (1992)
Crouser ED, Julian MW, Blaho DV, Pfeiffer DR, Crit.Care. Med., 30, 276 (2002)
Hempel SL, Monick MM, Hunninghake GW, Am. J. Respir.Cell Mol. Biol., 14, 170 (1996)
Schuller-Levis GB, Sturman JA, Activation of alveolar leukocytes isolated from cats fed taurine-free diets. In: Lombardini JB, Schaffer SW, Azuma J (Eds.), Taurine: nutritional value and mechanisms of action. New York, Plenum Press, 83 (1992)
Leeper-Woodford SK, Detmer K, Am. J. Physiol., 276, L909 (1992)
Shoemaker WC, Appel PL, Bishop MH, New Horiz., 1, 522 (1993)
Kao SJ, David W, Hen IL, Chen HI, Clinical and Experimental Pharmacology and Physiology., 33, 33 (2006)
Wang XQ, Zhou X, Zhou Y, Rong L, Gao L, Xu W, Respirology., 13(6), 772 (2008)
Timbrell JA, Seabra V, Waterfield CJ, Gen. Pharmacol., 26, 453 (1995)
Pritchard JH, Cunningham FG, MacDonald PC, Gant NF, Eclampsia regimen. In: Williams Textbook of Obstetrics, 18th Ed. Norwalk, CT:Appleton-Lange, 679 (1989)
Mathew R, Altura RM, Magnesium., 7, 173 (1998)
Nadler J, Wang I, Ehrlich L, Ryzen E, Francis R, Rude R, Clin. Res., 37, 333A (1989)
Dedhia HV, Banks DE, Environ. Health Perspect., 102, 101 (1994)
