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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received December 19, 2011
Accepted March 21, 2012

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effectiveness of antioxidant and membrane oxygenator in acute respiratory distress syndrome by endotoxin

Seong-Jong Kim Kyung-Hwa Kim¹ Shang-Jin Kim² Hyung-Sub Kang² Jin-Shang Kim² Min-Ho Kim³ Jung-Ku Jo³ Jong-Beum Choi³ Yeong-Seok Yang⁴ Sung-Jun Kang⁵ Gi-Beum Kim^2†

Division of Chemical Engineering, Chonbuk National University, 664-14 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Korea ¹Research Institute of Clinical Medicine, Chonbuk National University, Chonbuk National University Hospital, 664-14 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Korea ²Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University, 664-14 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Korea ³Chonbuk National University Medical Schools, 664-14 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Korea ⁴Division of Pharmaceutical Engineering, Woosuk University, 443, Samnye-ro, Samnye-eup, Wanju-gun, Jeonbuk 565-701, Korea ⁵Division of Mechanical System Engineering, Chonbuk National University, 664-14 1-Ga Dukjin-dong, Dukjin-gu, Jeonju, Jeonbuk 561-756, Korea

kgb70@jbnu.ac.kr

Korean Journal of Chemical Engineering, November 2012, 29(11), 1597-1603(7), 10.1007/s11814-012-0042-z

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Abstract

This study evaluated the effectiveness of antioxidants in animal models with damaged lungs such as inflammatory mediator-induced acute respiratory distress syndrome (ARDS) and established an ARDS therapy technique by suppressing active oxygen with membrane oxygenator. When inflammatory mediator that has an endotoxin, such as LPS, was injected directly into the airway, inflammatory pulmonary edema developed in the lung, and could induce_x000D_ ARDS. To treat such endotoxin-induced ARDS, the antioxidants such as taurine and dexamethasone were injected and their antioxidant effects were evaluated. They turned the blood pH to the normal condition, increased blood hemoglobin and hemocrit concentration and oxygen partial pressure (PO2), and improved survival. When a membrane oxygenator was used alone on the animal models with ARDS, similar antioxidant effects were identified. When a membrane oxygenator and antioxidants were used simultaneously, synergistic antioxidant effects were revealed. Therefore, the simultaneous use of antioxidants and membrane oxygenator is more effective than the use of either of them in treating the animal models with ARDS. This result indicates that bilateral use of antioxidants and membrane oxygenator may be useful as a potential therapy technique for the treatment of acute respiratory distress syndrome.

Keywords

ARDS Membrane Oxygenator Endotoxin Antioxidant Dexamethasone

References

Ashbaugh DG, Bigelow DB, Petty TL, Levine BE, Lancet., 2(3), 319 (1967)
Petty TL, Ashbaugh DG, Chest., 60, 233 (1971)
Villar J, Slutsky AS, Am. Reu. Respir. Dis., 40, 814 (1989)
Hanley ME, Repine JE, Sem. Respir. Crit. Care. Med., 15, 260 (1994)
Pearson GD, Short BE, J. Intens. Care. Med., 2, 116 (1986)
Finderv NN, Tierney AJ, Hayashi A, Peliowski A, Etches PC, J. Can. Med. Assoc., 146, 501 (1992)
Fazzalari FL, Bartlett RH, Bonnell MR, Montoya JP, J.Artif. Organs., 18, 801 (1994)
Vaslcf SN, Moekros LF, Anderson RW, Trans. Am. Soc.Artif. Intern. Organs., 35, 660 (1989)
Federspiel WJ, Hewitt T, Hout MS, Walters FR, Lund LW, Sawzik PJ, Reeder G, Borovetz HS, Hattler BG, ASAIO., 42, 435 (1996)
Federspiel WJ, Williams JL, Hattler BG, AIChE J., 42(7), 2094 (1996)
Fedespiel WJ, Hout MS, Hewitt TJ, Lund LW, Heinrich SW, Liwak P, Walters FR, Reeder GD, Borovetz HS, Hattler BG, ASAIO., 43, 725 (1997)
Kim GB, Kim SJ, Kim MH, Hong CU, Kang HS, J. Membr. Sci., 326(1), 130 (2009)
Kim GB, Kim SJ, Hong CU, Lee YC, Kim MH, J.Biomed. Eng. Res., 27, 143 (2006)
Kim GB, Hong CU, Kwon TK, J. Artifi. Organs., 9, 34 (2006)
Kim GB, Hong CU, Kwon TK, Jpn. J. Appl. Phys., 45, 3811 (2006)
Kim GB, Kim SJ, Hong CU, Kwon TK, Kim NG, Korean J. Chem. Eng., 22(4), 521 (2005)
Dorinsky PM, Gadek JE, Clin. Chest. Med., 11, 581 (1990)
Weiss SJ, N. Eng. J. Med., 321, 327 (1989)
Stephens KE, Ishizaka A, Larrick JW, Raffin TA, Am. Rev.Respir. Dis., 137, 1364 (1988)
Bernard GR, Artlgas A, Briqham KL, Carlet J, Falke K, Hudson L, Lamy M, Leqall JR, Morris A, Spraqq R, Am. J. Respir Crit. Care. Med., 149, 818 (1994)
Partrick DA, Moore EE, Silliman CC, Barnett CC, Kuypers FA, Crit. Care. Med., 29, 42 (2001)
Nagase T, Uozumi N, Ishii S, Kume K, Izumi T, Ouchi Y, Shimizu T, Nature Immunol., 1, 13 (2000)
Vernon LP, Bell JB, Pharmac. Ther., 54, 269 (1992)
Elin RJ, Hristova EN, Cecco SA, Niemela JE, Rehak NN, Scand. J. Clin. Lab. Invest., 56, 203 (1999)
Jeon SH, Lee MY, Rahman MM, Kim SJ, Kim GB, Park SY, Hong CU, Kim SZ, Kim JS, Kang HS, Pulm. Pharnacol. Ther., 22, 562 (2009)
Jeon SH, Park HM, Kim SJ, Lee NY, Kim GB, Rahman MM, Woo JN, Kim IS, Kim JS, Kang HS, Hum. Exp. Toxicol., 29, 627 (2009)