Biocomposite of bioactive glass (BG) with chitosan polymer (CH) is prepared by freeze-drying_x000D_ technique. Obtained material is investigated by using several physico-chemical methods. The XRD and FTIR show the interface bonding interactions between glass and polymer. The specific surface and porosity of biocomposite were determined. In vitro assays were employed to evaluate the effect of chitosan addition on the glass by studying the chemical reactivity and bioactivity of the BG and BG/CH biocomposite after soaking in a simulated body fluid (SBF). The obtained results show the formation of a bioactive hydroxycarbonate apatite (HCA) layer and highlight the bioactivity and the kinetics of chemical reactivity of bioactive glass, particularly after association with chitosan. The BG/CH biocomposite has excellent ability to form an apatite layer._x000D_ Inductively coupled plasma-optical emission spectrometry (ICP-OES) highlights the negative effect of chitosan on the silicon release toward the SBF of bioactive glass when in vitro assays.

Bioactive Glass Biocomposite “In vitro” Assays Bioactivity Freeze-drying

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