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Received December 30, 2011
Accepted July 14, 2012
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Reactive extraction of 2,3-butanediol from fermentation broth
Chemical Engineering Research Center, East China University of Science & Technology, Shanghai 200237, China
Korean Journal of Chemical Engineering, January 2013, 30(1), 154-159(6), 10.1007/s11814-012-0114-0
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Abstract
Biochemical 2,3-butanediol is a renewable material, but the lack of an effective separation process limits its industrial application. We developed an effective separation process to recover 2,3-butanediol from fermentation broth by reactive-extraction with ion-exchange resin HZ732 as catalyst. n-Butylaldehyde was used as both reactant and extractant. Feasible operation conditions were obtained as follows: room temperature, Ccat=200 g·L^(-1), three-stage cross-current extraction, with reactant ratio (VButylaldehyde : Vfermentation broth) 0.05 for each stage. Reactive-extraction can recover over 98% of 2,3-butanediol in the form of 2-propyl-4,5-dimethyl-1,3-dioxolane from fermentation broth. Then 2,3-butanediol was obtained by hydrolyzing 2-propyl-4,5-dimethyl-1,3-dioxolane and purified by vacuum distillation. The total yield rate of 2,3-butanediol through the process was over 94% and purity of final product reached 99%.
References
Ji XJ, Huang H, Ouyang PK, Biotechnol. Adv., 29, 351 (2011)
John W, Knowlton N, J. Amer. Chem. Soc., 68, 208 (1946)
Flickinger MC, Biotechnol. Bioeng., 22, 27 (1980)
Jansen NB, Flickinger MC, Tsao GT, Biotechnol. Bioeng., 26, 362 (1984)
Yu EKC, Levitin N, Biotechnol. Lett., 4, 741 (1982)
Palsson BO, Fathi-Afshar S, Rudd DF, Lightfoot EN, Sci., 213, 513 (1981)
Syu MJ, Appl. Microbiol. Biotechnol., 55, 10 (2010)
Wheat JA, Leslie JD, Tomkins RV, Mitton HE, Scott DS, Ledingham GA, Can. J. Res., 26F, 469 (1948)
Escudero I, Cabezas JL, Coca J, Chem. Eng. Commun., 175, 135 (1999)
Wu YY, Zhu JW, Chen K, Wu B, Shen YL, Fluid Phase Equilib., 266(1-2), 42 (2008)
Wu YY, Zhu JW, Chen K, Wu B, Fang J, Shen YL, Fluid Phase Equilib., 265(1-2), 1 (2008)
Wu YY, Zhu JW, Chen K, Wu B, Shen YL, J. Chem. Eng. Data, 53(2), 559 (2008)
Li ZG, Teng H, Xiu ZL, Proc. Biochem., 45, 731 (2010)
Dai JY, Li D, Zhang YL, Xiu ZL, J. Biotechnol., 150, 682 (2010)
Shao P, Kumar A, J. Membr. Sci., 329(1-2), 160 (2009)
Shao PH, Kumar A, Can. J. Chem. Eng., 89(5), 1255 (2011)
Xiang BT, Chen SF, Liu DH, J. Tsinghua Univ., 41, 53 (2001)
Xie ZM, Zhang WM, Zhang LM, Basic Chemistry, Science Press, Beijing (2009)
Malinowski JJ, Biotechnol. Prog., 16(1), 76 (2000)
Hao J, Liu HJ, Liu DH, Ind. Eng. Chem. Res., 44(12), 4380 (2005)
Xiu ZL, Zeng AP, Appl. Microbiol. Biotechnol., 78(6), 917 (2008)
Yoon S, Kwon SY, Lee CW, Korean J. Chem. Eng., 28(1), 71 (2011)
Zhang L, Xiu ZM, Yuan XQ, Elements of chemical reaction engineering, East China University of Science and Technology Press, Shanghai (2000)
Wang XP, Xing SL, Tianjin Chem. Ind., 23(3), 40 (2009)
Wu B, Zhu J, Chen K, Ji L, Guo J, Zhao J, Korean J. Chem. Eng., 20(2), 354 (2003)
John W, Knowlton N, J. Amer. Chem. Soc., 68, 208 (1946)
Flickinger MC, Biotechnol. Bioeng., 22, 27 (1980)
Jansen NB, Flickinger MC, Tsao GT, Biotechnol. Bioeng., 26, 362 (1984)
Yu EKC, Levitin N, Biotechnol. Lett., 4, 741 (1982)
Palsson BO, Fathi-Afshar S, Rudd DF, Lightfoot EN, Sci., 213, 513 (1981)
Syu MJ, Appl. Microbiol. Biotechnol., 55, 10 (2010)
Wheat JA, Leslie JD, Tomkins RV, Mitton HE, Scott DS, Ledingham GA, Can. J. Res., 26F, 469 (1948)
Escudero I, Cabezas JL, Coca J, Chem. Eng. Commun., 175, 135 (1999)
Wu YY, Zhu JW, Chen K, Wu B, Shen YL, Fluid Phase Equilib., 266(1-2), 42 (2008)
Wu YY, Zhu JW, Chen K, Wu B, Fang J, Shen YL, Fluid Phase Equilib., 265(1-2), 1 (2008)
Wu YY, Zhu JW, Chen K, Wu B, Shen YL, J. Chem. Eng. Data, 53(2), 559 (2008)
Li ZG, Teng H, Xiu ZL, Proc. Biochem., 45, 731 (2010)
Dai JY, Li D, Zhang YL, Xiu ZL, J. Biotechnol., 150, 682 (2010)
Shao P, Kumar A, J. Membr. Sci., 329(1-2), 160 (2009)
Shao PH, Kumar A, Can. J. Chem. Eng., 89(5), 1255 (2011)
Xiang BT, Chen SF, Liu DH, J. Tsinghua Univ., 41, 53 (2001)
Xie ZM, Zhang WM, Zhang LM, Basic Chemistry, Science Press, Beijing (2009)
Malinowski JJ, Biotechnol. Prog., 16(1), 76 (2000)
Hao J, Liu HJ, Liu DH, Ind. Eng. Chem. Res., 44(12), 4380 (2005)
Xiu ZL, Zeng AP, Appl. Microbiol. Biotechnol., 78(6), 917 (2008)
Yoon S, Kwon SY, Lee CW, Korean J. Chem. Eng., 28(1), 71 (2011)
Zhang L, Xiu ZM, Yuan XQ, Elements of chemical reaction engineering, East China University of Science and Technology Press, Shanghai (2000)
Wang XP, Xing SL, Tianjin Chem. Ind., 23(3), 40 (2009)
Wu B, Zhu J, Chen K, Ji L, Guo J, Zhao J, Korean J. Chem. Eng., 20(2), 354 (2003)
