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Received May 31, 2013
Accepted July 9, 2013
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Optimization of temperature swing strategy for selective cooling crystallization of α-form L-glutamic acid crystals
Department of Chemical and Biological Engineering, Korea University, Anam-dong 5-Ga, Seongbuk-gu, Seoul 136-701, Korea
Korean Journal of Chemical Engineering, October 2013, 30(10), 1836-1842(7), 10.1007/s11814-013-0124-6
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Abstract
L-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of L-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of L-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.
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References
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De Anda JC, Wang XZ, Lai X, Roberts KJ, J. Process Control, 15(7), 785 (2005)
Garti N, Zour H, J. Cryst. Growth., 172, 486 (1997)
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Cashell C, Corcoran D, Hodnett BK, Chem. Commun., 3, 374 (2003)
Roelands CPM, ter Horst JH, Kramer HJM, Jansens PJ, AIChE J., 53(2), 354 (2007)
Cornel J, Lindenberg C, Mazzotti M, Cryst. Growth Des., 9(1), 243 (2009)
Hatakka H, Alatalo H, Louhi-Kultanen M, Lassila I, Haeggstrom E, Chem. Eng. Technol., 33(5), 751 (2010)
Mo YX, Dang LP, Wei HY, Fluid Phase Equilib., 300(1-2), 105 (2011)
De Anda JC, Wang XZ, Lai X, Roberts KJ, Jennings KH, Wilkinson MJ, Watson D, Roberts D, AIChE J., 51(5), 1406 (2005)
Kee NCS, Tan RBH, Braatz RD, Cryst. Growth Des., 9(7), 3044 (2009)
Yang DR, Lee KS, Lee JS, Kim SG, Kim DH, Bang YK, Ind. Eng. Chem. Res., 46(24), 8158 (2007)
Kim DY, Paul M, Repke JU, Wozny G, Yang DR, Korean J. Chem. Eng., 26(5), 1220 (2009)
Worlitschek J, Mazzotti M, Cryst. Growth Des., 4(5), 891 (2004)
Czapla F, Haida H, Elsner MP, Lorenz H, Seidel-Morgenstern A, Chem. Eng. Sci., 64(4), 753 (2009)
Liu JJ, Ma CY, Hu YD, Wang XZ, Chem. Eng. Res. Des., 88(4A), 437 (2010)
Ma CY, Wang XZ, Roberts KJ, Adv. Powder Technol., 18(6), 707 (2007)
Ma CY, Wang XZ, Chem. Eng. Sci., 70, 22 (2012)
Kumar S, Ramkrishna D, Chem. Eng. Sci., 51(8), 1333 (1996)
Kumar S, Ramkrishna D, Chem. Eng. Sci., 52(24), 4659 (1997)
Gerstlauer A, Mitrovic A, Motz S, Gilles ED, Chem. Eng. Sci., 56(7), 2553 (2001)
McCoy BJ, J. Colloid Interface Sci., 240(1), 139 (2001)
McCoy BJ, Chem. Eng. Sci., 57(12), 2279 (2002)
Madras G, McCoy BJ, Powder Technol., 143-144, 297 (2004)
Puel F, Fevotte G, Klein JP, Chem. Eng. Sci., 58(16), 3715 (2003)
Puel F, Fevotte G, Klein JP, Chem. Eng. Sci., 58(16), 3729 (2003)
Gunawan R, Fusman I, Braatz RD, AIChE J., 50(11), 2738 (2004)
Hu Q, Rohani S, Wang DX, Jutan A, AIChE J., 50(8), 1786 (2004)
Hu Q, Rohani S, Jutan A, AIChE J., 51(11), 3000 (2005)
Fevotte F, Fevotte G, Chem. Eng. Sci., 65(10), 3191 (2010)
Silva LFLR, Rodrigues RC, Mitre JF, Lage PLC, Comput. Chem. Eng., 34(3), 286 (2010)
Samad NAFA, Singh R, Sin G, Gernaey KV, Gani R, Comput. Chem. Eng., 35(5), 828 (2011)
Scholl J, Bonalumi D, Vicum L, Mazzotti M, Muller M, Cryst.Growth Des., 6(4), 881 (2006)
Hermanto MW, Kee NC, Tan RBH, Chiu MS, Braatz RD, AIChE J., 54(12), 3248 (2008)
Qamar S, Noor S, Seidel-Morgenstern A, Ind. Eng. Chem. Res., 49(10), 4940 (2010)
Nagy ZK, Aamir E, Rielly CD, Cryst. Growth Des., 11, 2205 (2011)
