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Received March 14, 2013
Accepted June 27, 2013
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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In vitro small intestinal absorption and pH stability of tableted KIOM-C and KIOM-MA-128
Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja2-dong, Chuncheon, Kangwon-do 200-701, Korea 1TKM Converging Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea
jinkim@kangwon.ac.kr
Korean Journal of Chemical Engineering, October 2013, 30(10), 1929-1933(5), 10.1007/s11814-013-0114-8
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Abstract
Hot water extracts, KIOM-C and KIOM-MA-128, were formulated into tablets and three kinds of absorption enhancers were included in the tablets. The mixture of starch and lactose was used as an excipient, sodium carboxymethylcellulose as a disintegrating agent, and magnesium stearate as a binder. The weight ratio of water extract/excipient/disintegrating agent/absorption enhancer/binder was 80/7/10/2/1. The tablets were completely disintegrated in an aqueous_x000D_
solution in 40min, and the disintegration rates were almost the same with all the tablets tested. Among the enhancers, EDTA was the most effective in enhancing the in vitro small intestine absorption of KIOM-C and KIOM-MA-128.
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